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Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
http://hdl.handle.net/10091/16196
http://hdl.handle.net/10091/16196dfebe262-e8a0-4d46-8616-c5af3f031dd6
名前 / ファイル | ライセンス | アクション |
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Class_I_II_hybrid_inhibitory_oligodeoxynucleotide_exerts.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-01-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.fob.2012.11.002 | |||||
関連名称 | 10.1016/j.fob.2012.11.002 | |||||
キーワード | ||||||
主題 | iODN, Class I iODN, Class II iODN, Class I/II hybrid iODN, immunosuppression | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Ito, Yusuke
× Ito, Yusuke× Shigemori, Suguru× Sato, Takashi× Shimazu, Tomoyuki× Hatano, Konomi× Otani, Hajime× Kitazawa, Haruki× Shimosato, Takeshi |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Shimosato, Takeshi | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html | |||||
出版者 | ||||||
出版者 | ELSEVIER | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | FEBS Open Bio. 3:41-45 (2013) | |||||
書誌情報 |
FEBS Open Bio 巻 3, p. 41-45, 発行日 2013 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We designed class I/II hybrid inhibitory oligodeoxynucleotides (iODNs), called iSG, and found that the sequence 5′-TTAGGG-3′, which has a six-base loop head structure, and a 3′-oligo (dG)3–5 tail sequence are important for potent immunosuppressive activity. Interestingly, splenocytes isolated from ovalbumin (OVA)-immunized mice and treated with iSG3 showed suppression of not only interleukin (IL)-6, IL-12p35, IL-12p40, and interferon (IFN) γ mRNA expression, but also IL-4 and IL-13 mRNA expression. Thus, both Th2 and Th1 immune responses can be strongly suppressed by iODNs in splenocytes from allergen-immunized mice, suggesting usefulness in the treatment of diseases induced by over-active immune activation. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2211-5463 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/23847756/ | |||||
関連名称 | 23847756 | |||||
権利 | ||||||
権利情報 | Copyright© 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000339569800008 |