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Soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) level is a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in the coronary circulation has yet to be examined. Methods. Twenty-seven consecutive patients with ACS and 40 patients with effort angina pectoris (EAP) undergoing percutaneous coronary intervention (PCI) had levels of soluble LOX-1 and LOX-1 index measured in paired blood samples from aorta (Ao) and coronary sinus (CS) just prior to the PCI. Results.We found positive correlations between soluble LOX-1 levels in the Ao and CS in both ACS and EAP patients (????P \u003c 0.01, for both). The soluble LOX-1 levels in the Ao and CS were higher in ACS than in EAP patients (????P \u003c 0.01, for both).The levels of soluble LOX-1 and LOX-1 index of the CS were significantly greater than those of the Ao in both ACS and EAP patients (????P \u003c 0.01, for both). 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Soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) level is a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in the coronary circulation has yet to be examined. Methods. Twenty-seven consecutive patients with ACS and 40 patients with effort angina pectoris (EAP) undergoing percutaneous coronary intervention (PCI) had levels of soluble LOX-1 and LOX-1 index measured in paired blood samples from aorta (Ao) and coronary sinus (CS) just prior to the PCI. Results. We found positive correlations between soluble LOX-1 levels in the Ao and CS in both ACS and EAP patients (P \u003c 0.01, for both). The soluble LOX-1 levels in the Ao and CS were higher in ACS than in EAP patients (P \u003c 0.01, for both). The levels of soluble LOX-1 and LOX-1 index of the CS were significantly greater than those of the Ao in both ACS and EAP patients (P \u003c 0.01, for both). Receiver operating characteristic curves for ACS detection demonstrated high sensitivity and specificity for the soluble LOX-1 andLOX-1 index with no differences between the Ao and CS. Conclusions. The present study showed that circulating soluble LOX-1 originates from coronary circulation and soluble LOX-1 and LOX-1 index are useful biomarkers for ACS."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Misaka, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106223", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106224", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakamoto, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106225", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamaki, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106226", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugimoto, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106227", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kunii, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106228", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakazato, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106229", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saitoh, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106230", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sawamura, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106231", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishibashi, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106232", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeishi, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106233", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-09-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "25293063_17.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2014 Tomofumi Misaka et al. 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Significance of Soluble Lectin-Like Oxidized LDL Receptor-1 Levels in Systemic and Coronary Circulation in Acute Coronary Syndrome
http://hdl.handle.net/10091/00020849
http://hdl.handle.net/10091/00020849f7bf8086-ed31-47af-9d12-d51bfefe51d0
名前 / ファイル | ライセンス | アクション |
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25293063_17.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-09-12 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Significance of Soluble Lectin-Like Oxidized LDL Receptor-1 Levels in Systemic and Coronary Circulation in Acute Coronary Syndrome | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1155/2014/649185 | |||||
関連名称 | 10.1155/2014/649185 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Misaka, T
× Misaka, T× Suzuki, S× Sakamoto, N× Yamaki, T× Sugimoto, K× Kunii, H× Nakazato, K× Saitoh, S× Sawamura, T× Ishibashi, T× Takeishi, Y |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Sawamura, Tatsuya | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HafpjeAF.html | |||||
出版者 | ||||||
出版者 | HINDAWI PUBLISHING CORPORATION | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | BIOMED RESEARCH INTERNATIONAL.2014:649185(2014) | |||||
書誌情報 |
BIOMED RESEARCH INTERNATIONAL 巻 2014, p. 649185, 発行日 2014-05-07 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background. Soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) level is a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in the coronary circulation has yet to be examined. Methods. Twenty-seven consecutive patients with ACS and 40 patients with effort angina pectoris (EAP) undergoing percutaneous coronary intervention (PCI) had levels of soluble LOX-1 and LOX-1 index measured in paired blood samples from aorta (Ao) and coronary sinus (CS) just prior to the PCI. Results.We found positive correlations between soluble LOX-1 levels in the Ao and CS in both ACS and EAP patients (????P < 0.01, for both). The soluble LOX-1 levels in the Ao and CS were higher in ACS than in EAP patients (????P < 0.01, for both).The levels of soluble LOX-1 and LOX-1 index of the CS were significantly greater than those of the Ao in both ACS and EAP patients (????P < 0.01, for both). Receiver operating characteristic curves for ACS detection demonstrated high sensitivity and specificity for the solubleLOX-1 andLOX-1 indexwith no differences between theAo andCS. Conclusions.Thepresent study showed that circulating soluble LOX-1 originates from coronary circulation and soluble LOX-1 and LOX-1 index are useful biomarkers for ACS. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 2314-6133 | |||||
権利 | ||||||
権利情報 | © 2014 Tomofumi Misaka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=7&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000336166000001 |