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Methods: Fifty-nine patients with COPD, 20 ex-smokers without COPD and 20 healthy subjects who had never smoked were examined for dynamic hyperinflation by metronome-paced hyperventilation with respiratory rate increasing from 20 to 30 and 40 tidal breaths/min. Dynamic hyperinflation was evaluated as the decrease in inspiratory capacity (IC) following hyperventilation, and the effects of SAAC and SABA on dynamic hyperinflation were assessed. Results: COPD patients showed a significant increase in end-expiratory lung volume and a decrease in IC following hyperventilation, and ex-smokers without COPD also showed mild but significant dynamic hyperinflation. Multiple stepwise linear regression analysis revealed that the carbon monoxide transfer coefficient (DLco/V-A) and RV/TLC were significant and independent determinants of dynamic hyperinflation in COPD. Treatment with SAAC and SABA significantly increased IC at each respiratory rate, independently of the increases in FEV1. Furthermore, SABA significantly inhibited the decrease in IC due to hyperventilation. Conclusions: These findings suggest that lung hyperinflation following hyperventilation may be a useful method for detecting dynamic hyperinflation observed not only in patients with COPD but also in ex-smokers without COPD, and both SAAC and SABA are effective in reducing dynamic hyperinflation in COPD."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fujimoto, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8672", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshiike, F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8673", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasuo, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8674", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitaguchi, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8675", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Urushihata, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8676", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubo, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8677", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Honda, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8678", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "bronchodoilators.pdf", "filesize": [{"value": "234.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 234000.0, "url": {"label": "bronchodoilators.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4024/files/bronchodoilators.pdf"}, "version_id": "cd9d7c20-ffe4-4344-91aa-e210f417be42"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/425", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-11-08"}, "publish_date": "2007-11-08", "publish_status": "0", "recid": "4024", "relation": {}, "relation_version_is_last": true, "title": ["Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD"], "weko_shared_id": -1}
Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD
http://hdl.handle.net/10091/425
http://hdl.handle.net/10091/4256d58b6e1-663a-4901-96ac-9ae04e94c3b0
名前 / ファイル | ライセンス | アクション |
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bronchodoilators.pdf (234.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-11-08 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Fujimoto, K
× Fujimoto, K× Yoshiike, F× Yasuo, M× Kitaguchi, Y× Urushihata, K× Kubo, K× Honda, T |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Fujimoto, K | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yFfaHFkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Yasuo, M | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ypnegpkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Urushihata, K | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakhHVkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Honda, T | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDUHFkh.html | |||||
出版者 | ||||||
出版者 | Blackwell Publishing | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Respirology. 12(1): 93-99 (2007) | |||||
書誌情報 |
en : Respirology 巻 12, 号 1, p. 93-99, 発行日 2007-01 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ‘The definitive version is available at www.blackwell-synergy.com '. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1323-7799 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/j.1440-1843.2006.00963.x | |||||
関連名称 | 10.1111/j.1440-1843.2006.00963.x | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000242907000016 |