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However, it remains unclear which patients will develop fulminant hepatitis, or whether fulminant hepatitis is caused by host-related factors or by virus-related factors. A 30-yr-old man with a history of aplastic anemia since 3 yr of age underwent allogenic BMT, when HBsAb and HBcAb were positive but HBs antigen (HBsAg) was negative. The donor was negative for HBsAg, HBsAb and HBcAb. After transplantation, the patient was complicated by acute graft-vs.-host disease (GVHD), cytomegalovirus infection, intestinal thrombotic microangiopathy and aspergillus colitis. Chronic GVHD was well controlled by FK506 and prednisolone. Twenty months after transplantation, the patient was admitted with general fatigue and liver dysfunction and was found to be positive for HBsAg and HBeAg. His serum HBV-DNA level was \u003e 8.8 log of the genome equivalent (LGE)/mL. Therefore, he was diagnosed as having hepatitis B caused by HBV reactivation and 100 mg/d lamivudine treatment was started. However, jaundice and hepatic failure deteriorated and became fatal. On analysis of the HBV-DNA, two adjacent gene mutations in the core promoter region (T1762/A1764) were detected. Increased replication of the mutated HBV might have caused HBV reactivation which progressed to fulminant hepatitis."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kitano, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8907", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8908", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hanamura, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8909", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furuta, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8910", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ueno, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8911", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Rokuhara, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8912", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, E", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8913", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Umemura, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8914", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyosawa, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8915", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Fulminant hepatitis after BMT.pdf", "filesize": [{"value": "67.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 67300.0, "url": {"label": "Fulminant hepatitis after BMT.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4054/files/Fulminant hepatitis after BMT.pdf"}, "version_id": "821e1d0e-05cb-4efb-9a52-4ef9c33d80f0"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Fulminant hepatitis after allogenic bone marrow transplantation caused by reactivation of hepatitis B virus with gene mutations in the core promotor region", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Fulminant hepatitis after allogenic bone marrow transplantation caused by reactivation of hepatitis B virus with gene mutations in the core promotor region", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/218", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-05-14"}, "publish_date": "2007-05-14", "publish_status": "0", "recid": "4054", "relation": {}, "relation_version_is_last": true, "title": ["Fulminant hepatitis after allogenic bone marrow transplantation caused by reactivation of hepatitis B virus with gene mutations in the core promotor region"], "weko_shared_id": -1}
Fulminant hepatitis after allogenic bone marrow transplantation caused by reactivation of hepatitis B virus with gene mutations in the core promotor region
http://hdl.handle.net/10091/218
http://hdl.handle.net/10091/218d25afd67-796d-419f-8262-c36fda688a1a
名前 / ファイル | ライセンス | アクション |
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Fulminant hepatitis after BMT.pdf (67.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-05-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Fulminant hepatitis after allogenic bone marrow transplantation caused by reactivation of hepatitis B virus with gene mutations in the core promotor region | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/j.1600-0609.2006.00678.x | |||||
関連名称 | 10.1111/j.1600-0609.2006.00678.x | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kitano, K
× Kitano, K× Kobayashi, H× Hanamura, M× Furuta, K× Ueno, M× Rokuhara, A× Tanaka, E× Umemura, T× Kiyosawa, K |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Tanaka, E | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||
出版者 | ||||||
出版者 | BLACKWELL PUBLISHING | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | EUROPEAN JOURNAL OF HAEMATOLOGY. 77(3): 255-258 (2006) | |||||
書誌情報 |
EUROPEAN JOURNAL OF HAEMATOLOGY 巻 77, 号 3, p. 255-258, 発行日 2006-09 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The definitive version is available at www.blackwell-synergy.com. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0902-4441 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10668976 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000239510800011 |