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One reason for the poor outcome in ANKL is leukemic infiltration into multiple organs. The mechanisms of cell trafficking associated with the chemokine system have been investigated in NK cells. To clarify the mechanism of systemic migration of leukemic NK cells, we enrolled nine ANKL and six CNKL cases, and analyzed the expression profiles and functions of chemokine receptors by flowcytometry and chemotaxis assay. CXCR1 was detected on NK cells in all groups, and CCR5 was positive in all ANKL cells. Proliferating NK cells were simultaneously positive for CXCR1 and CCR5 in all ANKL patients examined, and NK cells with this phenotype did not expand in CNKL patients or healthy donors. ANKL cells showed enhanced chemotaxis toward the ligands of these receptors. These results indicated that the chemokine system might play an important role in the pathophysiology of ANKL and that chemokine receptor profiling might be a novel tool for discriminating ANKL cells from benign NK cells."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Makishima, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8916", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8917", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asano, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8918", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakazawa, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8919", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimodaira, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8920", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamijo, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8921", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakazawa, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8922", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8923", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8924", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyosawa, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8925", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishida, F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8926", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Chemokine receptors in ANKL.pdf", "filesize": [{"value": "413.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 413600.0, "url": {"label": "Chemokine receptors in ANKL.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4055/files/Chemokine receptors in ANKL.pdf"}, "version_id": "e691fd73-7555-4082-a0b7-4594ea4e9d16"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Significance of chemokine receptor expression in aggressive NK cell leukemia", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Significance of chemokine receptor expression in aggressive NK cell leukemia", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/217", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-05-14"}, "publish_date": "2007-05-14", "publish_status": "0", "recid": "4055", "relation": {}, "relation_version_is_last": true, "title": ["Significance of chemokine receptor expression in aggressive NK cell leukemia"], "weko_shared_id": -1}
Significance of chemokine receptor expression in aggressive NK cell leukemia
http://hdl.handle.net/10091/217
http://hdl.handle.net/10091/21787c55da6-139a-4692-adad-3c7978900f13
名前 / ファイル | ライセンス | アクション |
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Chemokine receptors in ANKL.pdf (413.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-05-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Significance of chemokine receptor expression in aggressive NK cell leukemia | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/sj.leu.2403732 | |||||
関連名称 | 10.1038/sj.leu.2403732 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Makishima, H
× Makishima, H× Ito, T× Asano, N× Nakazawa, H× Shimodaira, S× Kamijo, Y× Nakazawa, Y× Suzuki, T× Kobayashi, H× Kiyosawa, K× Ishida, F |
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出版者 | ||||||
出版者 | NATURE PUBLISHING GROUP | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | LEUKEMIA. 19(7): 1169-1174 (2005) | |||||
書誌情報 |
LEUKEMIA 巻 19, 号 7, p. 1169-1174, 発行日 2005-07 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0887-6924 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10668706 | |||||
他の資源との関係:URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.nature.com/leu/index.html | |||||
関連名称 | http://www.nature.com/leu/index.html | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
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