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Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer
http://hdl.handle.net/10091/00019823
http://hdl.handle.net/10091/000198231cd8ad15-a00f-40de-beaf-8fb81eb93ba8
名前 / ファイル | ライセンス | アクション |
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Dual_Roles_of_Gastric_Gland_Mucin-specific_O-glycans.pdf (2.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-09-20 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | expression cloning, glycosyltransferase, H. pylori, knockout mouse, mucin histochemistry | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Nakayama, Jun
× Nakayama, Jun |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Nakayama, Jun | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html | |||||
出版者 | ||||||
出版者 | JAPAN SOC HISTOCHEMISTRY & CYTOCHEMISTRY | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ACTA HISTOCHEMICA ET CYTOCHEMICA. 47(1):1-9 (2014) | |||||
書誌情報 |
ACTA HISTOCHEMICA ET CYTOCHEMICA 巻 47, 号 1, p. 1-9, 発行日 2014 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Gastric gland mucin is secreted from gland mucous cells, including pyloric gland cells and mucous neck cells located in the lower layer of the gastric mucosa. These mucins typically contain O-glycans carrying terminal alpha 1,4-linked N-acetylglucosamine residues (alpha GlcNAc) attached to the scaffold protein MUC6, and biosynthesis of the O-glycans is catalyzed by the glycosyltransferase, alpha 1,4-N-acetylglucosaminyltransferase (alpha 4GnT). We previously used expression cloning to isolate cDNA encoding alpha 4GnT, and then demonstrated that aGlcNAc functions as natural antibiotic against Helicobacter pylori, a microbe causing various gastric diseases including gastric cancer. More recently, it was shown that aGlcNAc serves as a tumor suppressor for differentiated-type adenocarcinoma. This review summarizes these findings and identifies dual roles for aGlcNAc in gastric cancer. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0044-5991 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508022 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/24761044 | |||||
関連名称 | 24761044 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1267/ahc.13034 | |||||
関連名称 | 10.1267/ahc.13034 | |||||
権利 | ||||||
権利情報 | © 2014 The Japan Society of Histochemistry and Cytochemistry | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000342658500001 |