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Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes
http://hdl.handle.net/10091/00021575
http://hdl.handle.net/10091/00021575f559762d-6dfa-4dd9-9d1c-51369200af8d
名前 / ファイル | ライセンス | アクション |
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2018_ArchBiochemBiophys_Mitani_SOAR.pdf (852.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-07-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.abb.2018.04.001 | |||||
関連名称 | 10.1016/j.abb.2018.04.001 | |||||
キーワード | ||||||
主題 | Adipocyte, CCAAT-Enhancer-binding proteins, Glucocorticoid receptor, Interleukin-6, Theophylline | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Mitani, Takakazu
× Mitani, Takakazu× Takaya, Tomohide× Harada, Naoki× Katayama, Shigeru× Yamaji, Ryoichi× Nakamura, Soichiro× Ashida, Hitoshi |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Mitani, Takakazu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ypcCPUkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Takaya, Tomohide | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yUcePUkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Katayama, Shigeru | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFkaPUkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Nakamura, Soichiro | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OpyhuNDp.html | |||||
出版者 | ||||||
出版者 | ELSEVIER SCIENCE INC | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS.646:98-106(2018) | |||||
書誌情報 |
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 巻 646, p. 98-106, 発行日 2018-05-15 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adipose tissues in obese individuals are characterized by a state of chronic low-grade inflammation. Pre-adipocytes and adipocytes in this state secrete pro-inflammatory adipokines, such as interleukin 6 (IL-6), which induce insulin resistance and hyperglycemia. Theophylline (1,3-dimethylxanthine) exerts anti-inflammatory effects, but its effects on pro-inflammatory adipokine secretion by pre-adipocytes and adipocytes have not been examined. In this study, we found that theophylline decreased IL-6 secretion by 3T3-L1 pre-adipocytes and mouse-derived primary pre-adipocytes. The synthetic glucocorticoid dexamethasone (DEX) induced IL-6 expression in 3T3-L1 pre-adipocytes, and this effect was suppressed by theophylline at the mRNA level. Knockdown of CCAAT/enhancer binding protein (C/EBP) δ inhibited DEX-induced IL-6 expression, and theophylline suppressed C/EBPδ expression. Furthermore, theophylline suppressed transcriptional activity of the glucocorticoid receptor (GR) through suppression of nuclear localization of GR. In vivo, glucocorticoid corticosterone treatment (100 μg/mL) increased fasting blood glucose and plasma IL-6 levels in C57BL/6 N mice. Theophylline administration (0.1% diet) reduced corticosterone-increased fasting blood glucose, plasma IL-6 levels, and Il6 gene expression in adipose tissues. These results show that theophylline administration attenuated glucocorticoid-induced hyperglycemia and IL-6 production by inhibiting GR activity. The present findings indicate the potential of theophylline as a candidate therapeutic agent to treat insulin resistance and hyperglycemia. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0003-9861 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00547159 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/29625124/ | |||||
関連名称 | 29625124 | |||||
権利 | ||||||
権利情報 | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000431838200013 |