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MethodsTwodays prior to cystometric investigations, the bladders of 10-week-old female Sprague-Dawley rats were cannulated. Cystometric measurements of the unanesthetized, unrestricted rats were taken to estimate baseline values at room temperature (RT, 272 degrees C) for 20min. They were then intravenously administered vehicle, 0.1, or 1.0mg/kg CL316243 (n=6 in each group). Fiveminutes after the treatments, they were gently and quickly transferred to the low temperature (LT, 42 degrees C) room for 40min where the cystometric measurements were again made. Afterward, the rats were returned to RT for final cystometric measurements. The cystometric effects of CL316243 were also measured at RT (n=6 in each group). Results\u003cp id=\"luts12050-para-0003\"\u003eAt RT, both low and high dose of CL316243 decreased basal and micturition pressure while the high dose (1.0mg/kg) significantly increased voiding interval and bladder capacity. During LT exposure, the high dose of CL316243 partially reduced cold stress-induced detrusor overactivity characterized by increased basal pressure and urinary frequency. The high drug dose also significantly inhibited the decreases of both voiding interval and bladder capacity compared to the vehicle- and low dose (0.1mg/kg)-treated rats. Conclusion\u003cp id=\"luts12050-para-0004\"\u003eA high dose of the beta-3 agonist CL316243 could modulate cold stress-induced detrusor overactivity. 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MethodsTwodays prior to cystometric investigations, the bladders of 10-week-old female Sprague-Dawley rats were cannulated. Cystometric measurements of the unanesthetized, unrestricted rats were taken to estimate baseline values at room temperature (RT, 272 degrees C) for 20min. They were then intravenously administered vehicle, 0.1, or 1.0mg/kg CL316243 (n=6 in each group). Fiveminutes after the treatments, they were gently and quickly transferred to the low temperature (LT, 42 degrees C) room for 40min where the cystometric measurements were again made. Afterward, the rats were returned to RT for final cystometric measurements. The cystometric effects of CL316243 were also measured at RT (n=6 in each group). Results\u003cp id=\"luts12050-para-0003\"\u003eAt RT, both low and high dose of CL316243 decreased basal and micturition pressure while the high dose (1.0mg/kg) significantly increased voiding interval and bladder capacity. During LT exposure, the high dose of CL316243 partially reduced cold stress-induced detrusor overactivity characterized by increased basal pressure and urinary frequency. The high drug dose also significantly inhibited the decreases of both voiding interval and bladder capacity compared to the vehicle- and low dose (0.1mg/kg)-treated rats. Conclusion\u003cp id=\"luts12050-para-0004\"\u003eA high dose of the beta-3 agonist CL316243 could modulate cold stress-induced detrusor overactivity. 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Pathways Involving Beta-3 Adrenergic Receptors Modulate Cold Stress-Induced Detrusor Overactivity in Conscious Rats
http://hdl.handle.net/10091/00021613
http://hdl.handle.net/10091/00021613a42ba06e-81c6-496d-bbb2-2e68e7606e22
名前 / ファイル | ライセンス | アクション |
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15K10622_05.pdf (871.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-09-09 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Pathways Involving Beta-3 Adrenergic Receptors Modulate Cold Stress-Induced Detrusor Overactivity in Conscious Rats | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/luts.12050 | |||||
関連名称 | 10.1111/luts.12050 | |||||
キーワード | ||||||
主題 | beta-3 adrenergic receptor, cold stress, detrusor overactivity, lower urinary tract symptoms, Sprague-Dawley rat | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Imamura, Tetsuya
× Imamura, Tetsuya× Ishizuka, Osamu× Ogawa, Teruyuki× Yamagishi, Takahiro× Yokoyama, Hitoshi× Minagawa, Tomonori× Nakazawa, Masaki× Nishizawa, Osamu |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Imamura, Tetsuya | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Ishizuka, Osamu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Ogawa, Teruyuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yhTUgpkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Minagawa, Tomonori | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jCfagUkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Nishizawa, Osamu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html | |||||
出版者 | ||||||
出版者 | WILEY-BLACKWELL | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | LUTS-LOWER URINARY TRACT SYMPTOMS.7(1):50-55(2014) | |||||
書誌情報 |
LUTS-LOWER URINARY TRACT SYMPTOMS 巻 7, 号 1, p. 50-55, 発行日 2014-03-02 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | ObjectiveTo investigate pathways involving beta-3 adrenergic receptors (ARs) in detrusor overactivity induced by cold stress, we determined if the beta-3 AR agonist CL316243 could modulate the cold stress-induced detrusor overactivity in normal rats. MethodsTwodays prior to cystometric investigations, the bladders of 10-week-old female Sprague-Dawley rats were cannulated. Cystometric measurements of the unanesthetized, unrestricted rats were taken to estimate baseline values at room temperature (RT, 272 degrees C) for 20min. They were then intravenously administered vehicle, 0.1, or 1.0mg/kg CL316243 (n=6 in each group). Fiveminutes after the treatments, they were gently and quickly transferred to the low temperature (LT, 42 degrees C) room for 40min where the cystometric measurements were again made. Afterward, the rats were returned to RT for final cystometric measurements. The cystometric effects of CL316243 were also measured at RT (n=6 in each group). Results<p id="luts12050-para-0003">At RT, both low and high dose of CL316243 decreased basal and micturition pressure while the high dose (1.0mg/kg) significantly increased voiding interval and bladder capacity. During LT exposure, the high dose of CL316243 partially reduced cold stress-induced detrusor overactivity characterized by increased basal pressure and urinary frequency. The high drug dose also significantly inhibited the decreases of both voiding interval and bladder capacity compared to the vehicle- and low dose (0.1mg/kg)-treated rats. Conclusion<p id="luts12050-para-0004">A high dose of the beta-3 agonist CL316243 could modulate cold stress-induced detrusor overactivity. Therefore, one of the mechanisms in cold stress-induced detrusor overactivity includes a pathway involving beta-3 ARs. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1757-5664 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12809467 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/26663652 | |||||
関連名称 | 26663652 | |||||
権利 | ||||||
権利情報 | This is the peer reviewed version of the following article: LUTS-LOWER URINARY TRACT SYMPTOMS.7(1):50-55(2015), which has been published in final form at [https://doi.org/10.1111/luts.12050]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000348738700009 |