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However, alpha(1)-adrenoceptor subtypes mediating the contraction of Mueller\u0027s muscle are still unclear. This study was designed to identify the alpha(1)-adrenoceptor subtypes in Mueller\u0027s muscle. Materials and Methods: A newly developed canine upper eyelid preparation was retrogradely perfused with a drug-containing Krebs-Henseleit solution through the angular vein in a temperature-controlled organ chamber. The contraction of the preparation was measured with a force-displacement transducer. Results: Phenylephrine, an alpha(1)-adrenoceptor agonist, increased the upper eyelid contractile force in a dose-dependent manner (K(0.5) = 110 nmol). Interestingly, the contraction in response to phenylephrine was persistent and hardly recovered to a base line level for more than 100 min after washout of the drug. 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However, alpha(1)-adrenoceptor subtypes mediating the contraction of Mueller\u0027s muscle are still unclear. This study was designed to identify the alpha(1)-adrenoceptor subtypes in Mueller\u0027s muscle. Materials and Methods: A newly developed canine upper eyelid preparation was retrogradely perfused with a drug-containing Krebs-Henseleit solution through the angular vein in a temperature-controlled organ chamber. The contraction of the preparation was measured with a force-displacement transducer. Results: Phenylephrine, an alpha(1)-adrenoceptor agonist, increased the upper eyelid contractile force in a dose-dependent manner (K(0.5) = 110 nmol). Interestingly, the contraction in response to phenylephrine was persistent and hardly recovered to a base line level for more than 100 min after washout of the drug. WB4101 (100 nM), an alpha(1A)- and alpha(1D)-adrenoceptor antagonist, but not BMY7378 (100 nM), a selective alpha(1D)-adrenoceptor antagonist, competitively inhibited the phenylephrine-induced contraction. ABT-866, a selective alpha(1A)-adrenoceptor agonist, increased the upper eyelid contractile force as effectively as phenylephrine in a dose-dependent manner (K(0.5) = 190 nmol), and the contraction continued again for more than 100 min. 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Selective alpha(1A)-Adrenoceptor Stimulation Induces Mueller's Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation
http://hdl.handle.net/10091/16900
http://hdl.handle.net/10091/169002e2692a1-347b-47c3-aab6-fccf5a411e25
名前 / ファイル | ライセンス | アクション |
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Selective_a1A-Adrenoceptor_Stimulation_Induces_Mueller’s_Smooth_Muscle_Contraction.pdf (379.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Selective alpha(1A)-Adrenoceptor Stimulation Induces Mueller's Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | alpha(1)-Adrenoceptors, Blepharoptosis, Canine, Eyelid, Mueller's smooth muscle | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yano, Shiharu
× Yano, Shiharu× Hirose, Masamichi× Nakada, Tsutomu× Nakayama, Jun× Matsuo, Kiyoshi× Yamada, Mitsuhiko |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Nakada, Tsutomu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OVkhuNkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Nakayama, Jun | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Yamada, Mitsuhiko | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCupca.html | |||||
出版者 | ||||||
出版者 | INFORMA HEALTHCARE | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | CURRENT EYE RESEARCH. 35(5):363-369 (2010) | |||||
書誌情報 |
CURRENT EYE RESEARCH 巻 35, 号 5, p. 363-369, 発行日 2010-05 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: It has been demonstrated that in patients with aponeurotic blepharoptosis, alpha(1)-adrenoceptor stimulation causes the contraction of the upper eyelid tarsal smooth muscle (Mueller's muscle) and opening of the eye. However, alpha(1)-adrenoceptor subtypes mediating the contraction of Mueller's muscle are still unclear. This study was designed to identify the alpha(1)-adrenoceptor subtypes in Mueller's muscle. Materials and Methods: A newly developed canine upper eyelid preparation was retrogradely perfused with a drug-containing Krebs-Henseleit solution through the angular vein in a temperature-controlled organ chamber. The contraction of the preparation was measured with a force-displacement transducer. Results: Phenylephrine, an alpha(1)-adrenoceptor agonist, increased the upper eyelid contractile force in a dose-dependent manner (K(0.5) = 110 nmol). Interestingly, the contraction in response to phenylephrine was persistent and hardly recovered to a base line level for more than 100 min after washout of the drug. WB4101 (100 nM), an alpha(1A)- and alpha(1D)-adrenoceptor antagonist, but not BMY7378 (100 nM), a selective alpha(1D)-adrenoceptor antagonist, competitively inhibited the phenylephrine-induced contraction. ABT-866, a selective alpha(1A)-adrenoceptor agonist, increased the upper eyelid contractile force as effectively as phenylephrine in a dose-dependent manner (K(0.5) = 190 nmol), and the contraction continued again for more than 100 min. Conclusion: These results suggest that selective alpha(1A)-adrenoceptor agonists, such as ABT-866, induce the sustained Mueller's muscle contraction and may be useful in pharmacological treatment of blepharoptosis. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0271-3683 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10621338 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20450248 | |||||
関連名称 | 20450248 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3109/02713680903518858 | |||||
関連名称 | 10.3109/02713680903518858 | |||||
権利 | ||||||
権利情報 | Copyright© 2010 Informa Healthcare USA, Inc. | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000282893900001 |