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Multiple roles of PPAR alpha in brown adipose tissue under constitutive and cold conditions
http://hdl.handle.net/10091/16260
http://hdl.handle.net/10091/162609e150938-3fda-43b5-833f-48b4a7700745
名前 / ファイル | ライセンス | アクション |
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Multiple_roles_PPAR_alpha_brown_adipose_tissue.pdf (5.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-02-13 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Multiple roles of PPAR alpha in brown adipose tissue under constitutive and cold conditions | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Komatsu, Makiko
× Komatsu, Makiko× Tong, Yuhong× Li, Yufeng× Nakajima, Takero× Li, Gang× Hu, Rui× Sugiyama, Eiko× Kamijo, Yuji× Tanaka, Naoki× Hara, Atsushi× Aoyama, Toshifumi |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Nakajima, Takero | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Kamijo, Yuji | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html | |||||
出版者 | ||||||
出版者 | WILEY-BLACKWELL PUBLISHING, INC | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | GENES TO CELLS. 15(2):91-100 (2010) | |||||
書誌情報 |
GENES TO CELLS 巻 15, 号 2, p. 91-100, 発行日 2010-02 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a member of the nuclear receptor family, regulating fatty acid degradation in many organs. Two-dimensional SDS-PAGE of brown adipose tissue (BAT) from PPAR alpha-null mice produced a higher-density spot. Proteomic analysis indicated that the protein was pyruvate dehydrogenase beta (PDH beta). To observe PDH beta regulation in BAT, the organ was stimulated by long-term cold exposure, and the activities of associated enzymes were investigated. Histological and biochemical analyses of BAT showed a significant decrease in the triglyceride content in wild-type mice and some degree of decrease in PPAR alpha-null mice on cold exposure. Analyses of molecules related to glucose metabolism showed that the expression of PDH beta is under PPAR alpha-specific regulation, and that glucose degradation ability may decrease on cold exposure. In contrast, analyses of molecules related to fatty acid metabolism showed that numerous PPAR alpha/gamma target molecules are induced on cold exposure, and that fatty acid degradation ability in wild-type mice is markedly enhanced and also increases to same degree in PPAR alpha-null mice on cold exposure. Thus, this study proposes novel and multiple roles of PPAR alpha in BAT. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1356-9597 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11078945 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20002497 | |||||
関連名称 | 20002497 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/j.1365-2443.2009.01368.x | |||||
関連名称 | 10.1111/j.1365-2443.2009.01368.x | |||||
権利 | ||||||
権利情報 | The definitive version is available at www3.intersience.wiley.com | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000274177800001 |