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In this study, we investigated the role of ASC in the host defense against Helicobacter pylori utilizing ASC-deficient mice. Mice were orally inoculated with H. pylori; bacterial load, degree of gastritis, and mucosal levels of inflammatory cytokines were analyzed and compared with those obtained from wild-type mice. We found more prominent H. pylori colonization in ASC-deficient mice, as revealed by colony-forming unit counts. Both groups of mice developed gastritis; however, ASC-deficient mice showed significant attenuation of inflammation despite high H. pylori colonization. ELISA, immunohistochemistry, and quantitative RT-PCR analyses revealed complete suppression of IL-1 beta and IL-18, and substantial reduction of interferon-gamma (IFN-gamma) expression, in ASC-deficient mice without apparent upregulation of other cytokines, including IL-10 and tumor necrosis factor-alpha. These results as a whole indicate that ASC exerts considerable influence on the host defense, acting through IL-1 beta/IL-18 and subsequent IFN-gamma production, which in turn contributes to continuous chronic inflammatory response and consequent reduction of H. pylori colonization. (J Histochem Cytochem 57:327-338, 2009)"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Benoit, BN", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8031", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8032", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawakubo, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8033", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeoka, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8034", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sano, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8035", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zou, J", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8036", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Itano, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8037", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsutsui, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8038", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Noda, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8039", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukuda, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8040", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakayama, J", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8041", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taniguchi, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8042", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "role_asc_pylori.pdf", "filesize": [{"value": "2.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2100000.0, "url": {"label": "role_asc_pylori.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3923/files/role_asc_pylori.pdf"}, "version_id": "7318e1e3-1ccc-4bf1-9310-f78959a2ce1e"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Role of ASC in the Mouse Model of Helicobacter pylori Infection", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Role of ASC in the Mouse Model of Helicobacter pylori Infection", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/3220", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-08-03"}, "publish_date": "2009-08-03", "publish_status": "0", "recid": "3923", "relation": {}, "relation_version_is_last": true, "title": ["Role of ASC in the Mouse Model of Helicobacter pylori Infection"], "weko_shared_id": -1}
Role of ASC in the Mouse Model of Helicobacter pylori Infection
http://hdl.handle.net/10091/3220
http://hdl.handle.net/10091/3220971004b1-a135-480d-bde3-f94690d839e0
名前 / ファイル | ライセンス | アクション |
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role_asc_pylori.pdf (2.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-08-03 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Role of ASC in the Mouse Model of Helicobacter pylori Infection | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1369/jhc.2008.952366 | |||||
関連名称 | 10.1369/jhc.2008.952366 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Benoit, BN
× Benoit, BN× Kobayashi, M× Kawakubo, M× Takeoka, M× Sano, K× Zou, J× Itano, N× Tsutsui, H× Noda, T× Fukuda, M× Nakayama, J× Taniguchi, S |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Nakayama, J | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Taniguchi, S | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HCyUHCDV.html | |||||
出版者 | ||||||
出版者 | The Histochemical Society | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Histochemistry and Cytochemistry. 57(4):327-338 (2009) | |||||
書誌情報 |
Journal of Histochemistry and Cytochemistry 巻 57, 号 4, p. 327-338, 発行日 2009-04 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0022-1554 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA0069926X | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/19064716 | |||||
関連名称 | 19064716 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000264257000004 |