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Although the HLA DRB1*0405-DQB1*0401 haplotype and Fc receptor-like 3 polymorphisms have been associated with AIP, the role of other genetic factors is largely unknown. As cytotoxic T-lymphocyte antigen 4 (CTLA4) polymorphisms have recently been linked with several autoimmune diseases, we sought to determine if CTLA4 polymorphisms and serum sCTLA4 levels were associated with AIP as well. METHODS: Five CTLA4 polymorphisms, located at -1722, -658, and -318 in the promoter, +49 in exon 1, and +6230 in the 3\u0027 untranslated region, were genotyped in 59 patients with AIP and 102 healthy subjects. Serum sCTLA4 levels were also determined in cohorts of 52 patients and 32 controls. RESULTS: Compared with healthy subjects, we found a significant increase in the +6230 G/G genotype (64% vs 42%, odds ratio [OR] 2.48, P = 0.011) in AIP patients. Haplotype 2, which had the +6230A, was associated with AIP resistance (OR 0.49, P = 0.011). The +49A/A and +6230A/A genotypes were associated with an enhanced risk of relapse (OR 5.45, P = 0.038 and OR 12.66, P = 0.022). Additionally, median serum sCTLA4 levels were significantly higher in patients with AIP (8.9 ng/mL) compared with healthy subjects (2.9 ng/mL, P \u003c 0.001). The +6230 G/A polymorphism did not influence sCTLA4 levels in AIP patients. CONCLUSIONS: Our findings suggest that AIP is associated with a genetic polymorphism in CTLA4 and is positively correlated with serum sCTLA4 levels. (Am J Gastroenterol 2008;103:588-594)."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Umemura, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8085", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8086", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hamano, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8087", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katsuyama, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8088", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Muraki, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8089", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arakura, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8090", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawa, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8091", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyosawa, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8092", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Association_of_Autoimmune.pdf", "filesize": [{"value": "168.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 168800.0, "url": {"label": "Association_of_Autoimmune.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3929/files/Association_of_Autoimmune.pdf"}, "version_id": "1642b89c-d0b3-4db9-aaad-f5b74b9dda71"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Association of Autoimmune Pancreatitis With Cytotoxic T-lymphocyte Antigen 4 Gene Polymorphisms in Japanese Patients", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Association of Autoimmune Pancreatitis With Cytotoxic T-lymphocyte Antigen 4 Gene Polymorphisms in Japanese Patients", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/3207", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-07-17"}, "publish_date": "2009-07-17", "publish_status": "0", "recid": "3929", "relation": {}, "relation_version_is_last": true, "title": ["Association of Autoimmune Pancreatitis With Cytotoxic T-lymphocyte Antigen 4 Gene Polymorphisms in Japanese Patients"], "weko_shared_id": -1}
Association of Autoimmune Pancreatitis With Cytotoxic T-lymphocyte Antigen 4 Gene Polymorphisms in Japanese Patients
http://hdl.handle.net/10091/3207
http://hdl.handle.net/10091/3207198ab7c8-1e76-424d-8d66-56669dde8fab
名前 / ファイル | ライセンス | アクション |
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Association_of_Autoimmune.pdf (168.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-07-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Association of Autoimmune Pancreatitis With Cytotoxic T-lymphocyte Antigen 4 Gene Polymorphisms in Japanese Patients | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/j.1572-0241.2007.01750.x | |||||
関連名称 | 10.1111/j.1572-0241.2007.01750.x | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Umemura, T
× Umemura, T× Ota, M× Hamano, H× Katsuyama, Y× Muraki, T× Arakura, N× Kawa, S× Kiyosawa, K |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Umemura, T | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Ota, M | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Kawa, S | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakeOVkh.html | |||||
出版者 | ||||||
出版者 | NATURE PUBLISHING GROUP | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | AMERICAN JOURNAL OF GASTROENTEROLOGY. 103(3):588-594 (2008) | |||||
書誌情報 |
AMERICAN JOURNAL OF GASTROENTEROLOGY 巻 103, 号 3, p. 588-594, 発行日 2008-03 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0002-9270 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00520662 | |||||
他の資源との関係:URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.nature.com/ajg/index.html | |||||
関連名称 | http://www.nature.com/ajg/index.html | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000253981800014 |