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Methods: Thirty-six female rats were fed with either a standard diet or one supplemented with 1.08%, Gosha-jinki-gan. After 4 weeks, the urinary bladders were instilled with either saline or 0.1% acetic acid. After 30 min, the bladders were removed and expression of the tachykinins and the TRPV1 and P2X3 receptors was determined by immunohistochemistry and mRNA expression. Results: In rats fed with the standard diet, the tachykinins and the TRPV1 and P2X3 receptors expressed neat-by or within urothelium of the acetic acid-treated rats increased compared with the saline-instilled rats. In rats pretreated with Gosha-jinki-gan, the tachykinins and the TRPV1 and P2X3 receptors in the acetic acid-treated rats also increased compared with the saline-instilled rats. However, with the instillation of acetic acid, the tachykinins and the TRPV1 and P2X3 receptors of Gosha-jinki-gan pretreated rats decreased compared with standard diet fed rats. The mRNA expression levels of neurokinin A, substance P, and the TRPV1 receptor in acetic acid-treated Gosha-jinki-gan pretreated rats were lower than that in acetic acid-treated standard diet fed rats. Gosha-jinki-gan did not destroy nerve fibers within the bladders. Conclusions: Gosha-jinki-gan partially reduced the tachykinins and TRPV1 and P2X3 purine receptors without destroying the nerve fibers. Neurourol. Urodynam. 27:832-837, 2008. (c) 2008 Wiley-Liss, Inc."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Imamura, Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8191", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishizuka, Osamu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8192", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aizawa, Naoki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8193", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhong, Chen", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8194", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogawa, Teruyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8195", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakayama, Tsuyoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8196", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanabe, Tomoaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8197", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishizawa, Osamu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8198", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Gosha-jinki-gan_Reduces_Transmitter.pdf", "filesize": [{"value": "364.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 364100.0, "url": {"label": "Gosha-jinki-gan_Reduces_Transmitter.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3946/files/Gosha-jinki-gan_Reduces_Transmitter.pdf"}, "version_id": "a83e8b88-9e36-49e0-b9ba-d0e7d5945e5d"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Gosha-jinki-gan Reduces Transmitter Proteins and Sensory Receptors Associated with C Fiber Activation Induced by Acetic Acid in Rat Urinary Bladder", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Gosha-jinki-gan Reduces Transmitter Proteins and Sensory Receptors Associated with C Fiber Activation Induced by Acetic Acid in Rat Urinary Bladder", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/3032", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-05-15"}, "publish_date": "2009-05-15", "publish_status": "0", "recid": "3946", "relation": {}, "relation_version_is_last": true, "title": ["Gosha-jinki-gan Reduces Transmitter Proteins and Sensory Receptors Associated with C Fiber Activation Induced by Acetic Acid in Rat Urinary Bladder"], "weko_shared_id": -1}
Gosha-jinki-gan Reduces Transmitter Proteins and Sensory Receptors Associated with C Fiber Activation Induced by Acetic Acid in Rat Urinary Bladder
http://hdl.handle.net/10091/3032
http://hdl.handle.net/10091/3032687a16c4-ad58-4972-8eac-259a3e0904c6
名前 / ファイル | ライセンス | アクション |
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Gosha-jinki-gan_Reduces_Transmitter.pdf (364.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-05-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Gosha-jinki-gan Reduces Transmitter Proteins and Sensory Receptors Associated with C Fiber Activation Induced by Acetic Acid in Rat Urinary Bladder | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Imamura, Tetsuya
× Imamura, Tetsuya× Ishizuka, Osamu× Aizawa, Naoki× Zhong, Chen× Ogawa, Teruyuki× Nakayama, Tsuyoshi× Tanabe, Tomoaki× Nishizawa, Osamu |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Imamura, Tetsuya | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Ishizuka, Osamu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Ogawa, Teruyuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yhTUgpkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Nishizawa, Osamu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html | |||||
出版者 | ||||||
出版者 | WILEY-LISS | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | NEUROUROLOGY AND URODYNAMICS. 27(8):832-837 (2008) | |||||
書誌情報 |
NEUROUROLOGY AND URODYNAMICS 巻 27, 号 8, p. 832-837, 発行日 2008 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This is a preprint of an article published in [NEUROUROLOGY AND URODYNAMICS. 27(8):832-837 (2008)]. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0733-2467 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10631557 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1002/nau.20559 | |||||
関連名称 | 10.1002/nau.20559 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000260811200020 |