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Methods: To examine the precise basis for the fibrinogen deficiency, mixtures of any two vectors, the fibrinogen Aalpha-, Bbeta-, gamma-(153Cys) or -gammam-(153Ala) chain were transfected into Chinese hamster ovary cells (CHO-Aalpha/gamma, -Aalpha/gammam, -Bbeta/gammam). Expression and constitution of each of two chains and their complexes in the individual CHO cell lines were identified by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE) and immunoblot analysis using polypeptide specific antibodies and two-dimensional electrophoresis (2-DE). Results: In the CHO-Aalpha/gamma and -Bbeta/gamma, the Aalpha/gamma- or Bbeta/gamma-complex was formed, whereas in the CHO-Aalpha/gammam and -Bbeta/gammam, no Aalpha/gammam- or Bbeta/gammam-complex was observed. These results demonstrate that gamma153Ala cannot assemble with the Aalpha- and Bbeta-chains, leading to impaired fibrinogen assembly and secretion. Conclusion: gamma153Cys is an essential residue for the fibrinogen assembly which is dependent on Aalpha/gamma- and Bbeta/gamma-complex formation. (C) 2004 Elsevier B.V. All rights reserved."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Terasawa, F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8475", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujita, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8476", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okumura, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8477", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CCA-Terasawa.pdf", "filesize": [{"value": "277.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 277500.0, "url": {"label": "CCA-Terasawa.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3992/files/CCA-Terasawa.pdf"}, "version_id": "8e355b5c-c873-4aa4-9b29-629640afbc31"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Residue gamma 153Cys is essential for the formation of the complexes A alpha gamma and B beta gamma, assembly intermediates for the A alpha B beta gamma complex and intact fibrinogen", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Residue gamma 153Cys is essential for the formation of the complexes A alpha gamma and B beta gamma, assembly intermediates for the A alpha B beta gamma complex and intact fibrinogen", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/1003", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-02-22"}, "publish_date": "2008-02-22", "publish_status": "0", "recid": "3992", "relation": {}, "relation_version_is_last": true, "title": ["Residue gamma 153Cys is essential for the formation of the complexes A alpha gamma and B beta gamma, assembly intermediates for the A alpha B beta gamma complex and intact fibrinogen"], "weko_shared_id": -1}
Residue gamma 153Cys is essential for the formation of the complexes A alpha gamma and B beta gamma, assembly intermediates for the A alpha B beta gamma complex and intact fibrinogen
http://hdl.handle.net/10091/1003
http://hdl.handle.net/10091/1003922050cb-9b4e-4abd-a2a9-96cd83593c57
名前 / ファイル | ライセンス | アクション |
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CCA-Terasawa.pdf (277.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-02-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Residue gamma 153Cys is essential for the formation of the complexes A alpha gamma and B beta gamma, assembly intermediates for the A alpha B beta gamma complex and intact fibrinogen | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.cccn.2004.10.017 | |||||
関連名称 | 10.1016/j.cccn.2004.10.017 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Terasawa, F
× Terasawa, F× Fujita, K× Okumura, N |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Fujita, K | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yUcauhkV.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Okumura, N | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OVnmgCkh.html | |||||
出版者 | ||||||
出版者 | ELSEVIER SCIENCE BV | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | CLINICA CHIMICA ACTA. 353(1-2): 157-164 (2005) | |||||
書誌情報 |
Clinica chimica acta 巻 353, 号 1-2, p. 157-164, 発行日 2005-03 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0009-8981 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00607421 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000227206600018 |