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Although the HLA-DRB1*0405 allele is associated with type 1 AIN in Japanese, the exact genetic etiology of AIN remains undefined. Recently, polymorphisms of Fc gamma receptors (Fc gamma R) and Fc receptor-like gene 3 (FCRL3) were linked to a variety of autoimmune diseases, and may be at least partially responsible for susceptibility to AIH. In this study, we genotyped Fc gamma RIIA, Fc gamma RIIB, and four FCRL3 polymorphisms in 87 Japanese patients with type 1 AIN and 97 ethnically matched controls using the TaqMan assay. Although we were able to detect significantly tower serum IgG concentrations in AN patients specifically with the FCRL3-110A/A genotype, we observed no difference in the distribution of the genotypes between patients and controls, implying that susceptibility to type 1 AN in Japanese patients is not influenced by Fc gamma RIIA, Fc gamma RIIB, or FCRL3 polymorphisms. (c) 2006 Elsevier Inc. 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Lack of association between FCRL3 and Fc gamma RII polymorphisms in Japanese type 1 autoimmune hepatitis
http://hdl.handle.net/10091/390
http://hdl.handle.net/10091/39099f9de71-2f2c-42be-b897-37c261b9d1ff
名前 / ファイル | ライセンス | アクション |
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CI-06-254 R1 final.pdf (281.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-10-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Lack of association between FCRL3 and Fc gamma RII polymorphisms in Japanese type 1 autoimmune hepatitis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Umemura, T
× Umemura, T× Ota, M× Yoshizawa, K× Katsuyama, Y× Ichijo, T× Tanaka, E× Kawa, S× Kiyosawa, K |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Ota, M | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Tanaka, E | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Kawa, S | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakeOVkh.html | |||||
出版者 | ||||||
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | CLINICAL IMMUNOLOGY. 122(3): 338-342 (2007) | |||||
書誌情報 |
Clinical immunology 巻 122, 号 3, p. 338-342, 発行日 2007-03 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1521-6616 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11301911 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.clim.2006.08.012 | |||||
関連名称 | 10.1016/j.clim.2006.08.012 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
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