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Of the 2795 patients who satisfied criteria for analysis after treatment from any of 30 medical institutions, 657 had received lamivudine and the remaining 2138 had not. A Cox regression model with liver biopsy as the starting point revealed seven factors related to HCC: lamivudine therapy, gender, family clustering of hepatitis B, age at liver biopsy, hepatic fibrosis stage, serum albumin level, and platelet count. In a matched case-controlled study, 377 patients in a lamivudine-treated group and 377 matched patients in a non-treated group were selected based on their propensity scores. The mean follow-up period was 2.7 years in the lamivudine group and 5.3 years in the control group. In the lamivudine group, HCC occurred in four patients (1.1 %) with an annual incidence rate of 0.4 %/(patient/year), whereas in the control group HCC occurred in 50 patients (13.3 %) for a rate of 2.5 %/(patient/year). A comparison of the cumulative HCC incidence between the two groups by the Kaplan-Meier method showed a significantly lower incidence of HCC in the lamivudine group (p \u003c 0.001). These findings suggest that lamivudine effectively reduces the incidence of HCC in patients with chronic hepatitis B. (c) 2005 Elsevier B.V. All rights reserved."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsumoto, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8873", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, E", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8874", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Rokuhara, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8875", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyosawa, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8876", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kumada, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8877", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Omata, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8878", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okita, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8879", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8880", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okanoue, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8881", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iino, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8882", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanikawa, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8883", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Lamivudine treatment suppresses the occurrence of HCC in chronic hepatitis B.pdf", "filesize": [{"value": "168.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 168500.0, "url": {"label": "Lamivudine treatment suppresses the occurrence of HCC in chronic hepatitis B.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4050/files/Lamivudine treatment suppresses the occurrence of HCC in chronic hepatitis B.pdf"}, "version_id": "26983c9c-2cca-4416-b4c3-263519a69e93"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/222", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-05-14"}, "publish_date": "2007-05-14", "publish_status": "0", "recid": "4050", "relation": {}, "relation_version_is_last": true, "title": ["Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients"], "weko_shared_id": -1}
Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients
http://hdl.handle.net/10091/222
http://hdl.handle.net/10091/222702c594c-dea7-43fd-990e-02fbacdbadf9
名前 / ファイル | ライセンス | アクション |
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Lamivudine treatment suppresses the occurrence of HCC in chronic hepatitis B.pdf (168.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-05-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.hepres.2005.02.006 | |||||
関連名称 | 10.1016/j.hepres.2005.02.006 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Matsumoto, A
× Matsumoto, A× Tanaka, E× Rokuhara, A× Kiyosawa, K× Kumada, H× Omata, M× Okita, K× Hayashi, N× Okanoue, T× Iino, S× Tanikawa, K |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Tanaka, E | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||
出版者 | ||||||
出版者 | ELSEVIER IRELAND LTD | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | HEPATOLOGY RESEARCH. 32(3): 173-184 (2005) | |||||
書誌情報 |
HEPATOLOGY RESEARCH 巻 32, 号 3, p. 173-184, 発行日 2005-07 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1386-6346 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11140867 | |||||
他の資源との関係:URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.elsevier.com/wps/find/journaldescription.cws_home/524224/description#description | |||||
関連名称 | http://www.elsevier.com/wps/find/journaldescription.cws_home/524224/description#description | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000231351700007 |