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Phase II Trial of Biweekly Paclitaxel and Gemcitabine as Second-Line Chemotherapy for Non-Small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy
http://hdl.handle.net/10091/13507
http://hdl.handle.net/10091/13507b40fd3af-9740-4401-94e6-4cf68da8f057
名前 / ファイル | ライセンス | アクション |
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Shinshu_med59-6-02.pdf (231.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2012-01-04 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Phase II Trial of Biweekly Paclitaxel and Gemcitabine as Second-Line Chemotherapy for Non-Small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | second-line chemotherapy, platinum-resistant, non-small cell lung cancer, neurotoxicity | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
KOBAYASHI, Takashi
× KOBAYASHI, Takashi× KOIZUMI, Tomonobu× YASUO, Masanori× TSUSHIMA, Kenji× YAMAMOTO, Hiroshi× KUBO, Keishi |
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信州大学研究者総覧へのリンク | ||||||
氏名 | KOIZUMI, Tomonobu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WakmHhkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | YASUO, Masanori | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ypnegpkh.html | |||||
出版者 | ||||||
出版者 | 信州医学会 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 信州医学雑誌 59(6): 411-418(2011) | |||||
書誌情報 |
信州医学雑誌 巻 59, 号 6, p. 411-418, 発行日 2011-12-10 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A phase II study was conducted to evaluate the feasibility and efficacy of biweekly administration of paclitaxel and gemcitabine in patients with non-small cell lung cancer (NSCLC) who had been treated previously with platinum-based chemotherapy. Paclitaxel (150 mg/m2) and gemcitabine (1,000 mg/m2) were administered biweekly for at least 4 cycles. Thirty-one patients with a median age of 64 years (39-75 years) were enrolled in this study(stage IIIB/IV :11/20,PS 0/1/2:13/16/2).Partial response was observed in 7 cases (23%), and stable disease was seen in 18 cases (58%).Median survival time was 8.8 months with a one-year survival rate of 41.9 %.Hematological toxicities were mild and neutropenia of grade 3 or above was observed in one patient (3%). Non-hematological toxicities were also mild, including neurotoxicity (3%). Biweekly paclitaxel and gemcitabine combination chemotherapy was effective and tolerated well as second-line therapy against NSCLC. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0037-3826 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00120815 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11441/shinshumedj.59.411 | |||||
関連名称 | 10.11441/shinshumedj.59.411 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |