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F344/DUラット門脈遮断後の再灌流は脾臓皮膜下注入ACL-15大腸癌細胞の肝転移を促進させる
http://hdl.handle.net/10091/13216
http://hdl.handle.net/10091/1321693f9e3d6-2af0-46d5-ad32-1126c6a63e02
名前 / ファイル | ライセンス | アクション |
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Shinshu_med59-4-05.pdf (746.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2011-08-18 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | F344/DUラット門脈遮断後の再灌流は脾臓皮膜下注入ACL-15大腸癌細胞の肝転移を促進させる | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Portal Vein Clamp and Subsequent Blood Reflow Enhance Liver Metastasis of Colon ACL-15 Cells Administered Intrasplenically in F344/DU Rats | |||||
言語 | ||||||
言語 | jpn | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11441/shinshumedj.59.249 | |||||
関連名称 | 10.11441/shinshumedj.59.249 | |||||
キーワード | ||||||
主題 | liver metastasis, portal vein clamp, colon cancer cell, congestion of the intestine 肝転移, 門脈遮断, 大腸癌細胞, 腸管鬱血 |
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資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
山本, 誠
× 山本, 誠× 麻沼, 和彦 |
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出版者 | ||||||
出版者 | 信州医学会 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 信州医学雑誌 59(4): 249-257(2011) | |||||
書誌情報 |
信州医学雑誌 巻 59, 号 4, p. 249-257, 発行日 2011-08-10 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We explored the relationship between transient portal vein clamping (TPVC)-induced adhesion molecule expression in the liver and liver metastasis. TPVC was achieved by clamping the portal vein of male F344/ DU rats for 15 min.For the investigation of liver metastasis,the portal vein was clamped in experimental rats and simple laparotomy was performed in control rats at the first operation.All rats were injected 6 and 18 h post-first surgery with 4.0x10^5 ACL-15 colon carcinoma cells intrasplenically. The number of tumor nodules on the liver surface was determined 14 days later.For the investigation of gene and protein expression in the liver,E-selectin, vascular cell adhesion molecule-1 (VCAM-1),and intercellular adhesion molecule-1 (ICAM- 1)were determined 6 or 18 h after the first operation by quantitative RT-PCR for m-RNAs and immunohistochemical staining for proteins.Portal vein-clamped rats had significantly more liver metastatic foci than did unclamped controls.TPVC enhanced mRNA and protein expression of E-selectin,VCAM-1,and ICAM-1 on the liver in experimental rats,except for m-RNA ICAM-1 expression at 18h post surgery.It is supposed that factors produced by TPVC can upregulate the mRNA and protein expression of E-selectin, VCAM-1, and ICAM-1 on the liver, which may facilitate liver metastasis. Shinshu Med J 59 : 249 ―257, 2011 | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0037-3826 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00120815 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |