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Essential role of gastric gland mucin in preventing gastric cancer in mice
http://hdl.handle.net/10091/16026
http://hdl.handle.net/10091/16026061efb51-e2e3-4e3c-94eb-3e4a53538c5a
名前 / ファイル | ライセンス | アクション |
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H23Kou916_karasawa.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-10-02 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Essential role of gastric gland mucin in preventing gastric cancer in mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Karasawa, Fumitoshi
× Karasawa, Fumitoshi× Shiota, Akira× Goso, Yukinobu× Kobayashi, Motohiro× Sato, Yoshiko× Masumoto, Junya× Fujiwara, Maiko× Yokosawa, Shuichi× Muraki, Takashi× Miyagawa, Shinichi× Ueda, Masatsugu× Fukuda, Michiko N.× Fukuda, Minoru× Ishihara, Kazuhiko× Nakayama, Jun |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Nakayama, Jun | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html | |||||
出版者 | ||||||
出版者 | AMER SOC CLINICAL INVESTIGATION INC | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF CLINICAL INVESTIGATION. 122(3):923-934 (2012) | |||||
書誌情報 |
JOURNAL OF CLINICAL INVESTIGATION 巻 122, 号 3, p. 923-934, 発行日 2012-03 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 信州大学博士(医学)・学位論文・平成24年3月31日授与(甲第916号)・唐澤文寿 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Gastric gland mucin secreted from the lower portion of the gastric mucosa contains unique O-linked oligosaccharides (O-glycans) having terminal alpha 1,4-linked N-acetylglucosamine residues (alpha GlcNAc). Previously, we identified human alpha 1,4-N-acetylglucosaminyltransferase (alpha 4GnT), which is responsible for the O-glycan biosynthesis and characterized alpha GlcNAc function in suppressing Helicobacter pylori in vitro. In the present study, we engineered A4gnt(-/-) mice to better understand its role in vivo. A4gnt(-/-) mice showed complete lack of alpha GlcNAc expression in gastric gland mucin. Surprisingly, all the mutant mice developed gastric adenocarcinoma through a hyperplasia-dysplasia-carcinoma sequence in the absence of H. pylori infection. Microarray and quantitative RT-PCR analysis revealed upregulation of genes encoding inflammatory chemokine ligands, proinflammatory cytokines, and growth factors, such as Ccl2, Il-11, and Hgf in the gastric mucosa of A4gnt(-/-) mice. Further supporting an important role for this O-glycan in cancer progression, we also observed significantly reduced alpha GlcNAc in human gastric adenocarcinoma and adenoma. Our results demonstrate that the absence of alpha GlcNAc triggers gastric tumorigenesis through inflammation-associated pathways in vivo. Thus, alpha GlcNAc-terminated gastric mucin plays dual roles in preventing gastric cancer by inhibiting H. pylori infection and also suppressing tumor-promoting inflammation. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021-9738 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695520 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=22307328 | |||||
関連名称 | 22307328 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1172/JCI59087 | |||||
関連名称 | 10.1172/JCI59087 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000301021500018 |