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High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly
http://hdl.handle.net/10091/16883
http://hdl.handle.net/10091/168837eeb061a-6481-4097-9ebe-cd652c4f22c3
| 名前 / ファイル | ライセンス | アクション |
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High_prevalence_wild-type_transthyretin_deposition_patients.pdf (819.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2013-04-01 | |||||||||||||||||||||||
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| タイトル | High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.humpath.2011.03.004 | |||||||||||||||||||||||
| 関連名称 | 10.1016/j.humpath.2011.03.004 | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Carpal tunnel syndrome, Transthyretin, Amyloid, Senile systemic amyloidosis, Aging | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Sekijima, Yoshiki
× Sekijima, Yoshiki
× Uchiyama, Shigeharu
× Tojo, Kana
× Sano, Kenji
× Shimizu, Yusaku
× Imaeda, Toshihiko
× Hoshii, Yoshibonu
× Kato, Hiroyuki
× Ikeda, Shu-ichi
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | Sekijima, Yoshiki | |||||||||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.WhLNuakh.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | Uchiyama, Shigeharu | |||||||||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.HmACupkh.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | Kato, Hiroyuki | |||||||||||||||||||||||
| URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | W B SAUNDERS CO-ELSEVIER INC | |||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||
| 内容記述 | HUMAN PATHOLOGY. 42(11):1785-1791 (2011) | |||||||||||||||||||||||
| 書誌情報 |
HUMAN PATHOLOGY 巻 42, 号 11, p. 1785-1791, 発行日 2011-11 |
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| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Carpal tunnel syndrome is the most common type of entrapment neuropathy. However, the cause of carpal tunnel syndrome remains unclear in most cases. Senile systemic amyloidosis, induced by wild-type transthyretin deposition, is a prevalent aging-related disorder and often accompanied by carpal tunnel syndrome. In this study, we measured the frequency of unrecognized wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome. One hundred twenty-three patients with carnal tunnel syndrome, including 100 idiopathic patients, treated by carpal tunnel release surgery were analyzed. Tenosynovial tissues obtained at surgery were analyzed by Congo red and immunohistochemical staining. If staining for transthyretin was positive, the entire transthyretin gene was analyzed by direct DNA sequencing. We also analyzed tenosynovial tissues from 32 autopsy cases as controls. Thirty-four patients (34.0%) with idiopathic carpal tunnel syndrome showed amyloid deposition in the tenosynovial tissue, and all amyloid showed specific immunolabeling with antitransthyretin antibody. Direct DNA sequencing of the entire transthyretin gene did not reveal any mutations, indicating that all amyloid deposits were derived form wild-type transthyretin. Statistical analysis using logistic regression showed that the prevalence of transthyretin deposition in the idiopathic carpal tunnel syndrome group was significantly higher than that in controls (odds ratio, 15.8; 95% confidence interval, 3.3-75.7), and age and male sex were independent risk factors for transthyretin amyloid deposition. Our results demonstrate that wild-type transthyretin deposition is a common cause of carpal tunnel syndrome in elderly men. It is likely that many patients develop carpal tunnel syndrome as an initial symptom of senile systemic amyloidosis. | |||||||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||
| 収録物識別子 | 0046-8177 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA00666191 | |||||||||||||||||||||||
| PubMed | ||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21733562 | |||||||||||||||||||||||
| 関連名称 | 21733562 | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | Copyright© 2011 Elsevier Inc. | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| WoS | ||||||||||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000297080700025 | |||||||||||||||||||||||
