2024-03-28T17:52:46Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003693
2022-12-14T04:07:47Z
461:462
Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults
Sasayama, Daimei
Hori, Hiroaki
Teraishi, Toshiya
Hattori, Kotaro
Ota, Miho
Matsuo, Junko
Kawamoto, Yumiko
Kinoshita, Yukiko
Amano, Naoji
Kunugi, Hiroshi
The original publication is available at www.springerlink.com
Cognitive function
Interleukin-6
Genetic polymorphism
Intelligence
Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory.
Article
JOURNAL OF NEURAL TRANSMISSION. 119(3):313-318 (2012)
SPRINGER WIEN
2012-03
eng
journal article
AM
http://hdl.handle.net/10091/17722
https://soar-ir.repo.nii.ac.jp/records/3693
https://pubmed.ncbi.nlm.nih.gov/21879314
21879314
https://doi.org/10.1007/s00702-011-0709-3
10.1007/s00702-011-0709-3
0300-9564
AA11077137
JOURNAL OF NEURAL TRANSMISSION
119
3
313
318
https://soar-ir.repo.nii.ac.jp/record/3693/files/Association_cognitive_performance_interleukin-6.pdf
application/pdf
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2015-09-24