2024-03-28T15:04:54Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003701
2022-12-14T03:49:09Z
461:462
Real-time imaging of the lymphatic channels and sentinel lymph nodes of the stomach using contrast-enhanced ultrasonography with Sonazoid in a porcine model
Kawai, Yoshiko
Ajima, Kumiko
Nagai, Takashi
Kaidoh, Maki
Ohhashi, Toshio
Copyright© 2011 Japanese Cancer Association.
The contrast-enhanced ultrasound (CEUS)-guided method in combination with Sonazoid has not been clinically or experimentally evaluated with regard to its use for identifying sentinel lymph node (SLN) in the stomach. Therefore, we attempted to evaluate the usefulness of the CEUS-guided method with Sonazoid for imaging of the lymphatic channels and SLN of the stomach in a porcine model by comparing it with the conventional Evans blue dye-guided method. Twenty-eight 2 to 3-month-old swine weighing 17-30 kg were used in this experiment. Anesthesia was maintained with 2.0-3.0% isoflurane/O(2) inhalation. Sonazoid was injected into the intra-and sub-mucosal layers of the stomach. The intragastric or transcutaneous CEUS-guided method was used to identify the lymphatic channels and SLN of the stomach. Contrast imaging using the CEUS-guided method with Sonazoid enabled us to produce clear images of the afferent lymph vessel and SLN of the stomach until 2 h after the injection of Sonazoid. In addition, intranodal flow of the microbubble agent could be clearly identified using tissue linear harmonic images of the SLN. The SLN detection rate was not significantly different between the CEUS- and dye-guided methods. However, the Evans blue dye flowed out quickly (similar to 15 min after the injection) through the true SLN into the next LN of stomach. In conclusion, the use of the CEUS-guided method with Sonazoid might be the most useful clinical procedure for producing real-time images of the SLN of the stomach, and the linear harmonic images are also useful for evaluating intranodal structure within the SLN. (Cancer Sci 2011; 102: 2073-2081)
Article
CANCER SCIENCE. 102(11):2073-2081 (2011)
WILEY-BLACKWELL
2011-11
eng
journal article
AM
http://hdl.handle.net/10091/17691
https://soar-ir.repo.nii.ac.jp/records/3701
https://pubmed.ncbi.nlm.nih.gov/21797945
21797945
https://doi.org/10.1111/j.1349-7006.2011.02048.x
10.1111/j.1349-7006.2011.02048.x
1347-9032
AA11808050
CANCER SCIENCE
102
11
2073
2081
https://soar-ir.repo.nii.ac.jp/record/3701/files/Real-time_imaging_lymphatic_channels.pdf
application/pdf
2.5 MB
2015-09-24