2024-03-29T00:27:37Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003722
2022-12-14T04:39:34Z
461:462
A Case of Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid: Immunohistochemical Comparison With the Normal Sweat Gland and Review of the Literature
Iwaya, Mai
Uehara, Takeshi
Yoshizawa, Akihiko
Kobayashi, Yukihiro
Momose, Masanobu
Honda, Takayuki
Ota, Hiroyoshi
Copyright© 2012 Lippincott Williams & Wilkins / This is a non-final version of an article published in final form in American Journal of Dermatopathology. 34(8):e139-e145, December 2012
eyelid
immunohistochemistry
mucin
sweat gland carcinoma
Primary signet-ring cell/histiocytoid carcinomas of the eyelid are extremely rare tumors considered to originate from sweat glands. Here, we report the case of a 72-year-old man diagnosed with primary signet-ring cell/histiocytoid carcinoma of the eyelid and present immunohistochemical analyses of the eyelid apocrine gland (Moll gland) and apocrine and eccrine sweat glands of perineum and axilla. Widespread infiltration of tumor cells with signet-ring cell or histiocytoid appearance was observed in his left eyelid, orbit, and periocular lesion. Tumor cells expressed mucins and showed immunoreactivity that was similar to that of the Moll gland: MUC6 (+), GlcNAc alpha 1 -> 4Gal -> R(-), MUC2(-), MUC5AC(-), GCDFP15(+), CD15(+), S100(-), CK7(+), CK20(-), ER(+), PgR (+), HER2(-), E-cadherin(+), p63(-), PSA(-), and TTF-1(-). The tumor cells differed from those of perineal and axillary apocrine and eccrine sweat glands, which were MUC6(-). The Moll gland was ER(-) and PgR(-), whereas perineal and axillar apocrine sweat glands were ER(+) and PgR(+), and perineal and axillary eccrine sweat glands were ER(+) and PgR(-). The tumor showed characteristics similar to that of the eyelid Moll gland, which is demonstrated to be an apocrine gland with a protein expression distinct from that of other apocrine glands. MUC6 and GCDFP15 expression are useful in identifying the Moll gland immunophenotype and GCDFP15, ER and PgR expression are useful in distinguishing primary eyelid signet-ring/histocytoid carcinoma from gastrointestinal malignancies.
Article
AMERICAN JOURNAL OF DERMATOPATHOLOGY. 34(8):E139-E145 (2012)
LIPPINCOTT WILLIAMS & WILKINS
2012-12
eng
journal article
AM
http://hdl.handle.net/10091/17617
https://soar-ir.repo.nii.ac.jp/records/3722
https://pubmed.ncbi.nlm.nih.gov/22935888
22935888
https://doi.org/10.1097/DAD.0b013e3182590ec1
10.1097/DAD.0b013e3182590ec1
0193-1091
AA00066321
AMERICAN JOURNAL OF DERMATOPATHOLOGY
34
8
E139
E145
https://soar-ir.repo.nii.ac.jp/record/3722/files/Primary_Signet-Ring_CellHistiocytoid_Carcinoma_Eyelid.pdf
application/pdf
1.5 MB
2015-09-24