2024-03-29T15:30:28Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003727
2022-12-14T03:49:08Z
461:462
Additive efficacy of short-acting bronchodilators on dynamic hyperinflation and exercise tolerance in stable COPD patients treated with long-acting bronchodilators
Kitaguchi, Yoshiaki
Fujimoto, Keisaku
Komatsu, Yoshimichi
Hanaoka, Masayuki
Honda, Takayuki
Kubo, Keishi
Copyright© 2012 Elsevier Ltd.
COPD
Dynamic hyperinflation
Exercise tolerance
Short-acting beta 2-agonists
Long-acting
Muscarinic antagonists
The purpose of this study was to clarify the additive efficacy of short-acting beta(2)-agonists (SABA) or muscarinic antagonists (SAMA) on dynamic hyperinflation and exercise tolerance in patients with chronic obstructive pulmonary disease (COPD) who had been treated with long-acting bronchodilators. Thirty-two patients with stable COPD who had been treated with long-acting bronchodilators, including long-acting muscarinic antagonists (LAMA), were examined by pulmonary function tests, dynamic hyperinflation evaluated by the method of step-wise metronome-paced incremental hyperventilation, and the incremental shuttle walking test before and after inhalation of SABA or SAMA. The additive efficacy of the two drugs was analyzed. Inhalation of SABA and SAMA improved airflow limitation and dynamic hyperinflation in stable COPD patients who had been treated with LAMA. Inhalation of SABA decreased respiratory resistance and the difference in respiratory resistance at 5 Hz and 20 Hz. On the whole, the additive efficacy of SABA on airflow limitation and dynamic hyperinflation was superior to that of SAMA. Furthermore, inhalation of SABA resulted in relief of breathlessness during exercise and significant improvement in exercise capacity. Inhalation of SABA resulted in significant improvement in exercise tolerance, which may have been due to improvement in dynamic hyperinflation. Single use of SABA before exercise, in addition to regular treatment with LAMA, may therefore be useful in stable COPD patients.
Article
RESPIRATORY MEDICINE. 107(3):394-400 (2013)
W B SAUNDERS CO LTD
2013-03
eng
journal article
AM
http://hdl.handle.net/10091/17607
https://soar-ir.repo.nii.ac.jp/records/3727
https://pubmed.ncbi.nlm.nih.gov/23245993
23245993
https://doi.org/10.1016/j.rmed.2012.11.013
10.1016/j.rmed.2012.11.013
0954-6111
AA10699492
RESPIRATORY MEDICINE
107
3
394
400
https://soar-ir.repo.nii.ac.jp/record/3727/files/Additive_efficacy_of_short-acting_bronchodilators_on_dynamic_hyperinflation.pdf
application/pdf
504.7 kB
2015-09-24