2024-03-29T13:01:13Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003728
2022-12-14T04:39:35Z
461:462
Transmission of Systemic AA Amyloidosis in Animals
Murakami, T
Ishiguro, N
Higuchi, K
The final, definitive version of this paper has been published in Veterinary Pathology, vol. 51 no. 2, March 2014 by SAGE Publications Ltd, All rights reserved. Copyright© 2014 American College of Veterinary Pathologists
prion-like transmission
cheetah
amyloid-enhancing factor
serum amyloid A
mouse
AA amyloidosis
bird
cattle
Amyloidoses are a group of protein-misfolding disorders that are characterized by the deposition of amyloid fibrils in organs and/or tissues. In reactive amyloid A (AA) amyloidosis, serum AA (SAA) protein forms deposits in mice, domestic and wild animals, and humans that experience chronic inflammation. AA amyloid fibrils are abnormal beta-sheet-rich forms of the serum precursor SAA, with conformational changes that promote fibril formation. Extracellular deposition of amyloid fibrils causes disease in affected animals. Recent findings suggest that AA amyloidosis could be transmissible. Similar to the pathogenesis of transmissible prion diseases, amyloid fibrils induce a seeding-nucleation process that may lead to development of AA amyloidosis. We review studies of possible transmission in bovine, avian, mouse, and cheetah AA amyloidosis.
Article
VETERINARY PATHOLOGY. 51(2):363-371 (2014)
SAGE PUBLICATIONS INC
2014-03
eng
journal article
AM
http://hdl.handle.net/10091/17606
https://soar-ir.repo.nii.ac.jp/records/3728
https://pubmed.ncbi.nlm.nih.gov/24280941
24280941
https://doi.org/10.1177/0300985813511128
10.1177/0300985813511128
0300-9858
AA00883666
VETERINARY PATHOLOGY
51
2
363
371
https://soar-ir.repo.nii.ac.jp/record/3728/files/Transmission_Systemic_AA_Amyloidosis_Animals.pdf
application/pdf
571.8 kB
2015-09-24