2024-03-29T13:13:28Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003821
2022-12-14T04:39:55Z
461:462
Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease
Hatta, Tomoko
Fujinaga, Yasunari
Kadoya, Masumi
Ueda, Hitoshi
Murayama, Hiroaki
Kurozumi, Masahiro
Ueda, Kazuhiko
Komatsu, Michiharu
Nagaya, Tadanobu
Joshita, Satoru
Kodama, Ryo
Tanaka, Eiji
Uehara, Tsuyoshi
Sano, Kenji
Tanaka, Naoki
The final publication is available at www.springerlink.com
Fatty liver
Magnetic resonance imaging
Water-oil phantom
Liver biopsy
To assess the degree of hepatic fat content, simple and noninvasive methods with high objectivity and reproducibility are required. Magnetic resonance imaging (MRI) is one such candidate, although its accuracy remains unclear. We aimed to validate an MRI method for quantifying hepatic fat content by calibrating MRI reading with a phantom and comparing MRI measurements in human subjects with estimates of liver fat content in liver biopsy specimens. The MRI method was performed by a combination of MRI calibration using a phantom and double-echo chemical shift gradient-echo sequence (double-echo fast low-angle shot sequence) that has been widely used on a 1.5-T scanner. Liver fat content in patients with nonalcoholic fatty liver disease (NAFLD, n = 26) was derived from a calibration curve generated by scanning the phantom. Liver fat was also estimated by optical image analysis. The correlation between the MRI measurements and liver histology findings was examined prospectively. Magnetic resonance imaging measurements showed a strong correlation with liver fat content estimated from the results of light microscopic examination (correlation coefficient 0.91, P < 0.001) regardless of the degree of hepatic steatosis. Moreover, the severity of lobular inflammation or fibrosis did not influence the MRI measurements. This MRI method is simple and noninvasive, has excellent ability to quantify hepatic fat content even in NAFLD patients with mild steatosis or advanced fibrosis, and can be performed easily without special devices.
Article
JOURNAL OF GASTROENTEROLOGY. 45(12):1263-1271 (2010)
SPRINGER TOKYO
2010-12
eng
journal article
AM
http://hdl.handle.net/10091/16249
https://soar-ir.repo.nii.ac.jp/records/3821
https://pubmed.ncbi.nlm.nih.gov/20625773
20625773
https://doi.org/10.1007/s00535-010-0277-6
10.1007/s00535-010-0277-6
0944-1174
AA10988015
JOURNAL OF GASTROENTEROLOGY
45
12
1263
1271
https://soar-ir.repo.nii.ac.jp/record/3821/files/Accurate_simple_method_quantification_hepatic_fat_content.pdf
application/pdf
442.9 kB
2015-09-24