2024-03-29T09:20:17Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003827
2022-12-14T04:40:24Z
461:462
Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection
Joshita, Satoru
Umemura, Takeji
Katsuyama, Yoshihiko
Ichikawa, Yuki
Kimura, Takefumi
Morita, Susumu
Kamijo, Atsushi
Komatsu, Michiharu
Ichijo, Tetsuya
Matsumoto, Akihiro
Yoshizawa, Kaname
Kamijo, Nozomi
Ota, Masao
Tanaka, Eiji
Copyright© 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc.
IL28B
SNP
HCC
HCV
Cirrhosis
IL28B single nucleotide polymorphisms (SNPs) are associated with spontaneous and treatment-induced elimination of hepatitis C virus (HCV). To assess whether the IL28B rs8099917 SNP also affects the progression of chronic HCV infection, we genotyped 511 Japanese HCV patients, including 69 with hepatocellular carcinoma (HCC). The T/T genotype of rs8099917 was not associated with the development of HCC (p = 0.623), although stepwise logistic regression analysis showed that liver cirrhosis, age greater than 68 years, and serum albumin <4.2 mg/dl were associated with HCC onset. It appears that the IL28B SNP does not directly influence hepatocarcinogenesis in chronic HCV infection.
Article
HUMAN IMMUNOLOGY. 73(3):298-300 (2012)
ELSEVIER SCIENCE INC
2012-03
eng
journal article
AM
http://hdl.handle.net/10091/16243
https://soar-ir.repo.nii.ac.jp/records/3827
https://pubmed.ncbi.nlm.nih.gov/22245236
22245236
https://doi.org/10.1016/j.humimm.2011.12.021
10.1016/j.humimm.2011.12.021
0198-8859
AA00214087
HUMAN IMMUNOLOGY
73
3
298
300
https://soar-ir.repo.nii.ac.jp/record/3827/files/Association_IL28B_Gene_Polymorphism_Development_Hepatocellular_Carcinoma.pdf
application/pdf
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