2024-03-29T12:17:50Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003864
2022-12-14T04:20:02Z
461:462
Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels
Tsutsui, Masaru
Tanaka, Naoki
Kawakubo, Masatomo
Sheena, Yo
Horiuchi, Akira
Komatsu, Michiharu
Nagaya, Tadanobu
Joshita, Satoru
Umemura, Takeji
Ichijo, Tetsuya
Matsumoto, Akihiro
Yoshizawa, Kaname
Aoyama, Toshifumi
Tanaka, Eiji
Sano, Kenji
cytokeratin 18
AST
ALT
NAFLD activity score
Background and Goals: Reliable noninvasive biomarkers to assess the histologic activity of nonalcoholic fatty liver disease (NAFLD) have not been established. As the frequency of Mallory bodies is known to be closely associated with the disease severity, we hypothesized that serum levels of Mallory body-related proteins were correlated with NAFLD histologic activity and evaluated this possibility. Study: Serum levels of total and fragmented cytokeratin (CK) 18, heat shock protein (Hsp) 70, Hsp90 alpha, ubiquitin + 1, and p38 alpha at the time of liver biopsy were measured in 118 NAFLD patients and their association with histologic findings and NAFLD histologic activity score (NAS) was investigated. Results: Serum levels of both forms of CK18 and Hsp90 alpha were markedly higher in patients having nonalcoholic steatohepatitis (NASH) compared with non-NASH ones. Both forms of CK18 significantly correlated with degree of steatosis, lobular inflammation, and ballooning, and showed stronger positive correlations with NAS than serum aspartate and alanine aminotransferase (AST and ALT). Multiple regression analysis further revealed that fragmented CK18 and AST were effective predictors of NAS, with the former being the more definitive of the two (P < 0.001 vs. 0.005). In 20 NAFLD patients who received a follow-up biopsy, changes in fragmented CK18 levels, but not AST or ALT levels, closely paralleled those in NAS. Conclusions: These results establish the usefulness of fragmented CK18 measurement for assessing and monitoring the histologic activity of NAFLD.
Article
JOURNAL OF CLINICAL GASTROENTEROLOGY. 44(6):440-447 (2010)
LIPPINCOTT WILLIAMS & WILKINS
2010-07
eng
journal article
AM
http://hdl.handle.net/10091/11103
https://soar-ir.repo.nii.ac.jp/records/3864
https://pubmed.ncbi.nlm.nih.gov/20104187
20104187
https://doi.org/10.1097/MCG.0b013e3181bdefe2
10.1097/MCG.0b013e3181bdefe2
0192-0790
AA00257261
JOURNAL OF CLINICAL GASTROENTEROLOGY
44
6
440
447
https://soar-ir.repo.nii.ac.jp/record/3864/files/Serum_fragmented_cytokeratin_18_levels.pdf
application/pdf
449.6 kB
2015-09-24