2024-03-29T05:47:53Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003868
2022-12-14T04:40:21Z
461:462
Low toxicity of a conditioning with 8-Gy total body irradiation, fludarabine and cyclophosphamide as preparative regimen for allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies
Yanagisawa, Ryu
Nakazawa, Yozo
Sakashita, Kazuo
Tanaka, Miyuki
Shikama, Naoto
Kamijo, Takehiko
Shiohara, Masaaki
Koike, Kenichi
intermediate dose of TBI-containing regimen
fludarabine
HLA-mismatched donors
allogeneic hematopoietic stem cell transplantation
pediatric hematological malignancies
The definitive version is available at www.blackwell-synergy.com
We here report the efficacy and toxicity of a conditioning regimen with fractionated 8-Gy TBI, fludarabine, and cyclophosphamide in allogeneic HSCT for pediatric hematological malignancies. Among 22 children who received related or unrelated HSCT, nine were transplanted with refractory disease and/or from HLA two or more loci-mismatched family donors. None of the patients developed graft failure. The Seattle grading system revealed that 18 patients had no RRT, and the remaining patients had grade I gastrointestinal toxicity alone. The estimated overall survival and leukemia-free survival at two yr were 57.1% and 48.0%, respectively, in 10 patients with acute lymphoblastic leukemia; 91.7% and 71.3%, respectively, in 12 patients with myeloid leukemia. The incidence of TRM was 4.8% at two yr. The rates of RRT above grade II and TRM in an 8-Gy TBI-containing regimen were significantly lower than the data of historical control patients who underwent 12-Gy TBI and cyclophosphamide with or without etoposide. The intermediate-dose TBI-based conditioning regimen may confer successful engraftment combined with minimized RRT, although its efficacy should be further evaluated.
Article
PEDIATRIC TRANSPLANTATION. 13(6):737-745 (2009)
WILEY-BLACKWELL PUBLISHING, INC
2009-09
eng
journal article
AM
http://hdl.handle.net/10091/11099
https://soar-ir.repo.nii.ac.jp/records/3868
https://pubmed.ncbi.nlm.nih.gov/19207225
19207225
https://doi.org/10.1111/j.1399-3046.2008.01065.x
10.1111/j.1399-3046.2008.01065.x
1397-3142
AA11202523
PEDIATRIC TRANSPLANTATION
13
6
737
745
https://soar-ir.repo.nii.ac.jp/record/3868/files/Low_toxicity_conditioning_8-Gy_total_body_irradiation.pdf
application/pdf
435.0 kB
2015-09-24