2024-03-29T11:38:39Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003889
2022-12-14T03:46:32Z
461:462
Upper limb neuropathy such as carpal tunnel syndrome as an initial manifestation of ATTR Val30Met familial amyloid polyneuropathy
Tojo, Kana
Tsuchiya-Suzuki, Ayako
Sekijima, Yoshiki
Morita, Hiroshi
Sumita, Naoko
Ikeda, Shu-ichi
Carpal tunnel syndrome
familial amyloid polyneuropathy
Val30Met
This is an electronic version of an article published in Amyloid 2010, Vol. 17, No. 1 : Pages 32-35. Amyloid is available online at: http://informahealthcare.com/doi/pdf/10.3109/13506121003619369
We report here two patients with amyloidogenic transthyretin (ATTR) Val30Met familial amyloid polyneuropathy (FAP) who developed numbness in both hands and were diagnosed as having bilateral carpal tunnel syndrome (CTS). In both patients systemic TTR amyloidosis consisting of polyneuropathy affecting both upper and lower limbs and/or autonomic dysfunction gradually appeared after surgery for CTS. Although CTS associated with TTR amyloidosis has been known as an initial symptom in some patients with ATTR non-Val30Met FAP and those with senile systemic amyloidosis, this is the first report of ATTR Val30Met FAP patients starting with upper limb neuropathy including CTS-like symptoms. It is also notable that both patients had no genealogical relationship with two Japanese endemic foci of this disease.
Article
AMYLOID. 17(1):32-35 (2010)
INFORMA HEALTHCARE
2010-03
eng
journal article
AM
http://hdl.handle.net/10091/11075
https://soar-ir.repo.nii.ac.jp/records/3889
https://pubmed.ncbi.nlm.nih.gov/20132088
20132088
https://doi.org/10.3109/13506121003619369
10.3109/13506121003619369
1350-6129
AA11096426
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
17
1
32
35
https://soar-ir.repo.nii.ac.jp/record/3889/files/Upper_limb_neuropathy_carpal_tunnel_syndrome.pdf
application/pdf
138.3 kB
2015-09-24