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残存髄膜腫の増大様式と腫瘍容積倍加時間の解析
Analysis of Growth Pattern and Tumor Volume Doubling Time of Residual Meningiomas
山本, 有希子
木村, 仁志
田中, 雄一郎
多田, 剛
本郷, 一博
小林, 茂昭
doubling time
meningioma
MIB-1 index
recurrence
倍加時間
髄膜腫
MIB-1値
再発
The purpose of the present study was to determine the growth pattern and growth rate of residual meningiomas. We investigated the tumor volume doubling time (Td) based on serial MRIs and the tumor proliferative potential by the MIB-1 staining index in 17 residual meningiomas. During a follow-up period ranging from 2 to 120 months, there were seven rapid-growing meningiomas with a Td of 14.3±9.6 months, six slow-growing tumors with a Td of 81.3±14.3 months, and four shrinking tumors. The majority of the growing tumors increased in size constantly in an exponential fashion,except for 2 small slow-growing tumors which showed a fluctuating growth pattern.There was a significant correlation between the MIB-1 index and Td with a correlation coefficient of -0.54.We conclude that repeated observations of residual meningiomas with MRI and MIB-1 staining index are important for the prediction of future tumor growth.
Article
信州医学雑誌 49(5): 257-262(2001)
信州医学会
2001-10
jpn
journal article
VoR
http://hdl.handle.net/10091/9304
https://soar-ir.repo.nii.ac.jp/records/4330
0037-3826
AN00120815
信州医学雑誌
49
5
257
262
https://soar-ir.repo.nii.ac.jp/record/4330/files/Shinshu_Med49-5-04.pdf
application/pdf
341.8 kB
2015-09-24