2024-03-29T00:20:51Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00007197
2022-12-14T03:54:12Z
461:848:849
Hemodialysis-Induced P-Wave Signal-Averaged Electrocardiogram Alterations Are Indicative of Vulnerability to Atrial Arrhythmias
Shimada, Kentaro
Tomita, Takeshi
Kamijo, Yuji
Higuchi, Makoto
Ito, Kenichi
Koizumi, Yoichi
Yamamoto, Kazuya
Aizawa, Kazunori
Koshikawa, Megumi
Kasai, Hiroki
Izawa, Atsushi
Miyashita, Yusuke
Kumazaki, Setsuo
Koyama, Jun
Ikeda, Uichi
Atrial fibrillation
Hemodialysis
P-wave signal-averaged electrocardiogram
信州大学博士(医学)・学位論文・平成24年1月30日授与(甲第923号)・嶋田健太郎
Background: Atrial fibrillation (AF) is the most common supraventricular arrhythmia, often occurring during hemodialysis (HD). Prolongation of the total filtered P-wave duration (PWD) and reduction of the root mean square voltages for the last 20 ms of the P wave (RMS20) on a P-wave signal-averaged electrocardiogram (P-SAECG) are predictors of AF. We investigated whether HD induces alterations of P-SAECG, and determined the influential factors. Methods and Results: Thirty-three end-stage kidney disease patients (66.7 +/- 12.6 years, 23 males) undergoing maintenance HD were enrolled in this study. Digital ambulatory P-SAECG monitoring and laboratory examination of serum proteins and ions were carried out before, during, and after the HD sessions. Data were analyzed by multiple regression analysis. PWD was significantly prolonged, and RMS20 significantly reduced, during HD. These values recovered after completion of HD. Multiple regression analysis showed that prolongation of PWD significantly correlated with HD duration and the rate of removal of body fluid. On the other hand, RMS20 significantly correlated with HD duration and blood urea nitrogen variation. Conclusions: HD resulted in prolongation of PWD and reduction of RMS20, indicating the vulnerability of HD patients to AF. These P-SAECG changes correlated with HD duration and the rate of removal of the body fluid. These findings underline the importance of the control of dialysis variables in the prevention of atrial arrhythmias following HD. (Circ J 2012; 76: 612-617)
Article
CIRCULATION JOURNAL. 76(3):612-617 (2012)
JAPANESE CIRCULATION SOC
2012-03
eng
journal article
VoR
http://hdl.handle.net/10091/16846
https://soar-ir.repo.nii.ac.jp/records/7197
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=22240596
22240596
https://doi.org/10.1253/circj.CJ-11-1000
10.1253/circj.CJ-11-1000
1346-9843
AA11591968
CIRCULATION JOURNAL
76
3
612
617
https://soar-ir.repo.nii.ac.jp/record/7197/files/H24Kou923_Shimada.pdf
application/pdf
350.0 kB
2015-09-25