2024-03-28T10:39:53Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00007200
2022-12-14T04:32:08Z
461:848:849
American ginseng improves neurocognitive function in senescence-accelerated mice: Possible role of the upregulated insulin and choline acetyltransferase gene expression
Shi, Shun
Shi, Reika
Hashizume, Kiyoshi
American ginseng
choline acetyltransferase
insulin; neurocognitive function
senescence-accelerated mouse
信州大学博士(医学)・学位論文・平成23年3月31日授与(甲第905号)・史峻
Aim: To investigate the effects of American ginseng on neurocognitive function and glucose regulation in senescence-accelerated mice. Methods: Male senescence-resistant inbred strains (SAMR1) and senescence-prone inbred strains (SAMP10) mice were divided into five groups and fed either a control diet or an American ginseng-supplemented diet (1% or 2% g/g) from 6 weeks to 10 months of age. Bodyweight, levels of fasting plasma glucose (FPG) and grading scores were monitored every month and neurocognitive functions were evaluated at 9 months of age with a KUROBOX apparatus using a stress-free positive cue task. Gene expressions of peroxisome proliferator-activated receptor delta (PPAR-d), insulin, choline acetyltransferase (ChAT) and amyloid precursor protein (APP) in the brain were measured by real-time quantitative reverse transcription polymerase chain reaction assays. Results: American ginseng decreased FPG in SAMR1 mice, but increased FPG in SAMP10 mice. Correct visit ratios were higher in both SAMR1 and SAMP10 strains consuming an American ginseng-supplemented diet. Gene upregulation of insulin and ChAT in the brain, but not of PPAR-d or APP, was evident in American ginseng-fed groups. Conclusion: Daily consumption of American ginseng induced an enhancement in neurocognitive function in senescence-accelerated mice, which could be related to the upregulation of insulin and ChAT gene expression in the brain. Geriatr Gerontol Int 2012; 12: 123-130.
Article
GERIATRICS & GERONTOLOGY INTERNATIONAL. 12(1):123-130 (2012)
WILEY-BLACKWELL
2012-01
eng
journal article
VoR
http://hdl.handle.net/10091/16032
https://soar-ir.repo.nii.ac.jp/records/7200
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=21702872
21702872
https://doi.org/10.1111/j.1447-0594.2011.00719.x
10.1111/j.1447-0594.2011.00719.x
1444-1586
AA1155729X
GERIATRICS & GERONTOLOGY INTERNATIONAL
12
1
123
130
https://soar-ir.repo.nii.ac.jp/record/7200/files/H23Kou905_Shi.pdf
application/pdf
522.8 kB
2015-09-25