2024-03-29T09:08:15Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00008024
2022-12-14T04:00:34Z
882:883
Cutaneous sarcoidosis in a chronic hepatitis C patient receiving pegylated interferon and ribavirin therapy
Joshita, Satoru
Shirahata, Kumiko
Yazaki, Yoshikazu
Okaniwa, Shinji
Nakamura, Yoshiyuki
Kimura, Takefumi
Noami, Sugiko
Horigome, Reiko
Yagi, Hikaru
Ito, Nobuo
Yamazaki, Asami
Akahane, Yuki
Umemura, Takeji
Yoshizawa, Kaname
Tanaka, Eiji
Ota, Masao
The definitive version is available at www.blackwell-synergy.com
human leukocyte antigen
pegylated interferon
ribavirin
sarcoidosis
A 61-year-old Japanese woman suffered from a small, painful, subcutaneous nodule on the sole of her foot that was 10mm across in diameter during pegylated interferon (PEG IFN) and ribavirin (RBV) combination therapy for chronic hepatitis C. Skin biopsy revealed multiple non-caseating granulomas composed of epithelioid histiocytes with multinucleate giant cells, which was consistent with sarcoidosis. Ophthalmologic examination revealed uveitis. Thoracic computed tomography (CT) showed multiple bilateral hilar lymphadenopathies and a diffuse micronodular interstitial pattern of the lungs. Genetic analysis indicated a probable homozygous haplotype of A*02:01-C*15:02-B*51:01-DRB1*16:02-DQB1*05:02 in human leukocyte antigen regions. The patient was observed carefully without any additional medication because no significant systemic symptoms were noted. Combination therapy was continued for 2months afterwards. She was asymptomatic for over 3years of follow up, and repeated hematological and biological investigations and chest CT showed improvement. In conclusion, clinicians should bear sarcoidosis in mind as a complication during PEG IFN and RBV combination therapy. They should also be aware of the usually good prognosis of PEG IFN-induced cutaneous sarcoidosis in order not to prematurely discontinue a treatment necessary for liver disease; maintenance of PEG IFN treatment may be advised with careful follow up.
Article
HEPATOLOGY RESEARCH. 43(7):801-807 (2013)
WILEY-BLACKWELL
2013-07
eng
journal article
AM
http://hdl.handle.net/10091/17645
https://soar-ir.repo.nii.ac.jp/records/8024
https://pubmed.ncbi.nlm.nih.gov/23675767
23675767
https://doi.org/10.1111/hepr.12021
10.1111/hepr.12021
1386-6346
AA11140867
HEPATOLOGY RESEARCH
43
7
801
807
https://soar-ir.repo.nii.ac.jp/record/8024/files/Cutaneous_sarcoidosis_chronic_hepatitis_C_patient.pdf
application/pdf
2.0 MB
2015-09-25