2024-03-28T11:49:42Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00008076
2022-12-14T04:00:49Z
882:883
Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma
Miyamoto, Tsutomu
Asaka, Ryouichi
Suzuki, Akihisa
Takatsu, Akiko
Kashima, Hiroyasu
Shiozawa, Tanri
Copyright© 2011 Elsevier Inc.
Endometrium
Endometrial carcinoma
SLC22A17
Lipocalin2
Immunohistochemistry
Background: We previously reported the overexpression of lipocalin2 (LCN2), a 25 kDa secretory protein involved in iron-transportation, in endometrial carcinoma and its possible contribution to endometrial carcinogenesis. Recently, a specific receptor for LCN2, solute carrier family 22 member 17 (SLC22A17), was identified. The present study was undertaken to investigate the expression of SLC22A17 in endometrial carcinoma. Methods: The expression of the SLC22A17 and LCN2 proteins was examined immunohistochemically using 69 cases of endometrial carcinoma and adjacent normal endometrial tissues. Immunoreactivity was evaluated according to the percentage of positive cells and described as a positivity index (PI, full score 100). Results: The expression of SLC22A17 was negligible in normal endometria, but positive staining for SLC22A17 (PI 1) was observed in 35 cases of endometrial carcinoma. The PI for SLC22A17 was significantly higher in cases with histological grade 3 (P < 0.0005), advanced FIGO stage (P=0.002), deep myometrial invasion (P=0.029), positive lymph-vascular space invasion (P = 0.029), positive intraperitoneal cytology (P = 0.020) and adnexal metastasis (P= 0.029). The expression of SLC22A17 and LCN2 was positively correlated with a significant difference (P= 0.002), and the patients who overexpressed both SLC22A17 and LCN2 showed poorer survival than those without the expression of SLC22A17 or LCN2 (P= 0.002). Moreover, the overexpression of both SLC22A17 and LCN2 was indicated to be an independent prognostic factor by multivariable analysis. Conclusions: These results suggested that SLC22A17, in cooperation with LCN2, to be involved in the acquisition of aggressive behavior among endometrial carcinoma cells.
Article
EXPERIMENTAL AND MOLECULAR PATHOLOGY. 91(2):563-568 (2011)
ACADEMIC PRESS INC ELSEVIER SCIENCE
2011-10
eng
journal article
AM
http://hdl.handle.net/10091/16808
https://soar-ir.repo.nii.ac.jp/records/8076
https://pubmed.ncbi.nlm.nih.gov/21763306
21763306
https://doi.org/10.1016/j.yexmp.2011.06.002
10.1016/j.yexmp.2011.06.002
0014-4800
AA00641168
EXPERIMENTAL AND MOLECULAR PATHOLOGY
91
2
563
568
https://soar-ir.repo.nii.ac.jp/record/8076/files/Immunohistochemical_detection_specific_receptor_lipocalin2.pdf
application/pdf
1.6 MB
2015-09-25