2024-03-29T14:05:25Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00010237
2022-12-14T04:10:38Z
1016:1017
Oral administration of a fruiting body extract of Boletopsis leucomelas enhances intestinal IgA production in LPS-challenged mice
Shimosato, Takeshi
Kanoh, Junko
Otani, Hajime
This is an Accepted Manuscript of an article published by Taylor & Francis in Food and Agricultural Immunology. Published online: 17 Oct 2013, available online at: http://www.tandfonline.com/10.1080/09540105.2013.847064 .
Boletopsis leucomelas
Kurokawa
LPS challenge
IgA
adaptive immunity
The present study showed that a hot water extract of the fruiting body of the edible mushroom Boletopsis leucomelas, known as 'Kurokawa' Japanese, strongly stimulated IgA-production in mouse spleen cells in our screening experiment. The in vivo study was also conducted with the objective of enhancing adaptive immune response by oral administration of the hot water extract of B. leucomelas (BLE) in lipopolysaccharide (LPS)-challenged mice. The mice were fed a standard diet with or without 0.16% BLE. The mice were also orally administered sodium phosphate buffer or LPS weekly at days 7, 14 and 21. Results indicated that LPS-specific serum IgG, IgM and IgA were increased in the BLE diet group compared to the standard diet group. Interestingly, intestinal total IgA and LPS-specific IgA were significantly increased in the BLE diet group. Moreover, the <1000 Da, 5000-10,000 Da phenol sulphate-positive molecules from BLE showed significant IgA-producing activity.
Article
FOOD AND AGRICULTURAL IMMUNOLOGY. 25(4):510-522 (2014)
TAYLOR & FRANCIS LTD
2014-01
eng
journal article
AM
http://hdl.handle.net/10091/18082
https://soar-ir.repo.nii.ac.jp/records/10237
https://doi.org/10.1080/09540105.2013.847064
10.1080/09540105.2013.847064
0954-0105
AA10779820
FOOD AND AGRICULTURAL IMMUNOLOGY
25
4
510
522
https://soar-ir.repo.nii.ac.jp/record/10237/files/Oral_administration_fruiting_body_extract.pdf
application/pdf
715.6 kB
2015-09-25