2024-03-29T12:33:19Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00010308
2022-12-14T04:01:59Z
1016:1017
Lactobacillus crispatus KT-11 Enhances Intestinal Immune Functions in C3H/HeN Mice
Tobita, Keisuke
Yanaka, Hiroyuki
Otani, Hajime
Copyright (c) 2011 by the Center for Academic Publications Japan
日本ビタミン学会, 日本栄養・食糧学会
Lactobacillus crispatus KT-11
immunoglobulin A
innate immune system
C3H/HeN mouse
Peyer's patch
We investigated the effect of Lactobacillus crispatus KT-11 (KT-11) on intestinal immune systems in C3H/HeN mice. The level of intestinal total immunoglobulin (Ig) A was significantly higher in mice given KT-11 than in mice not given KT-11. Gene expression relating to antibody production and innate immune response increased more than 2-fold in the former compared with the later. Moreover, the number of IL-6(+)C11b(+) cells was significantly higher in Peyer's patch cells cultured with KT-11 than in those cultured without KT-11, although the number of CD4(+) cells and the cell ratio of CD4(+)/CD8(+) were remarkably lower in the culture with KT-11. These results indicate that KT-11 enhances intestinal IgA production and innate immune response in C3H/HeN mice.
Article
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY. 56(6): 441-445(2010)
CENTER ACADEMIC PUBL JAPAN
2010-12
eng
journal article
VoR
http://hdl.handle.net/10091/13189
https://soar-ir.repo.nii.ac.jp/records/10308
10.3177/jnsv.56.441
https://doi.org/10.3177/jnsv.56.441
10.3177/jnsv.56.441
0301-4800
AA00703822
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
56
6
441
445
https://soar-ir.repo.nii.ac.jp/record/10308/files/Lactobacillus_crispatus_KT-11_Enhances.pdf
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2015-09-25