2024-03-29T13:14:29Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00010667
2023-01-05T06:46:47Z
1016:1018:1019:1045
The Influence of Mixing Conditions of Reaction Medium on Protease-Catalyzed Peptide Synthesis: The Use of Sonication
プロテアーゼ触媒によるペプチド合成へおよぼす攪拌条件の影響:超音波の利用
TADASA, Kohji
YAMAMOTO, Yoshihiro
SHIMODA, Ichizo
KAYAHARA, Hiroshi
Sonication was demonstrated to be a useful method mixing reactoin medium. A model reaction, Boc-Gly-OH + H-Phe-N₂H₂Ph → Boc-Gly-phe-N₂H₂Ph, was adopted to compare two mixing methods of medium, sonication and magnetic-stirring. Under biphasic system including 25% of organic solvent, sonication was preferable to magnetic-stirring for several cosolvents and showed being able to have some potentiality as mixing method. On the other hand another model reaction, Boc-Tyr (Bzl)-OH + H-Gly-N₂H₂Ph→Boc-Tyr (Bzl)-Gly-N₂H₂Ph, which had not been achieved by other investigators, was progressed by the new mixing method. This new method may form other certain reaction-field in the medium.
Article
信州大学農学部紀要 26(1・2): 21-26(1990)
信州大学農学部
1990-01-30
eng
departmental bulletin paper
VoR
http://hdl.handle.net/10091/2463
https://soar-ir.repo.nii.ac.jp/records/10667
0583-0621
AN00121352
信州大学農学部紀要
26
1・2
21
26
https://soar-ir.repo.nii.ac.jp/record/10667/files/Agriculture26-03.pdf
application/pdf
236.3 kB
2015-09-25