2026-03-11T10:22:50Z https://soar-ir.repo.nii.ac.jp/oai

oai:soar-ir.repo.nii.ac.jp:00011412 2022-12-14T04:41:25Z 1016:1154:1156

Immune Function of Probiotic Bacterial DNA and Their Advanced Application to Food Immunology プロバイオティックDNAの免疫機能と食品免疫学への応用 SHIMOSATO, Takeshi probiotics immunobiotics immunostimulatory DNA Functional Foods / Feeds The toll-like receptor (TLR) family plays an important role in host defense through recognizing bacterial pathogen-associated molecular patterns. The induction of the host defense system begins with the recognition of pathogens. To date, 13 types of TLR, which function as a kind of pathogen sensor, have been identified. Our recent research on the physiological function of food products has investigated the immunoregulatory effects of probiotic lactic acid bacteria (LAB) via TLR. On the basis of our study, efforts have been made to develop a molecular immunoassay system for probiotic LAB and find novel immunostimulatory DNA sequences from probiotics and high potential immunobiotic LAB strains via TLR9 signaling. These findings may provide important clues at the molecular level on TLR signal transduction pathways and recognition mechanisms for the ligands. In addition to identifying immunoregulatory factor immunogenics from LAB, a better understanding of intestinal immune regulation through cytokine networks holds out promise for basic food immunology research and the development of immunobiotic foods/feeds to prevent specific diseases. Other Shinshu University International Symposium 2010 : Sustainable Agriculture and Environment : Asian Networks II 　信州大学国際シンポジウム2010 : 持続的農業と環境 : アジアネットワークII ― アジアネットワークの発展をめざして―. 信州大学農学部, 2010, 93-97 信州大学国際シンポジウム2010実行委員会 2010-02-20 eng conference paper VoR http://hdl.handle.net/10091/10801 https://soar-ir.repo.nii.ac.jp/records/11412 Shinshu University International Symposium 2010 : Sustainable Agriculture and Environment : Asian Networks II 　信州大学国際シンポジウム2010 : 持続的農業と環境 : アジアネットワークII ― アジアネットワークの発展をめざして― 93 97 https://soar-ir.repo.nii.ac.jp/record/11412/files/proc2-4.pdf application/pdf 1.4 MB 2015-09-25