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Acetyl-L-carnitine enhances myelination of regenerated fibers of the lateral olfactory tract
Fukushima, Nanae
Yokouchi, Kumiko
Kuroiwa, Masafumi
Kawagishi, Kyutaro
Moriizumi, Tetsuji
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Olfactory tract injury
Spontaneous regeneration
Acetyl-l-carnitine
Myelinated axons
Neonatal rats
It is well known that acetyl-L-carnitine (ALC) has various neuroprotective effects against neurodegenerative diseases. In addition, it has been reported that ALC facilitates myelination of regenerated axons after peripheral nerve injuries. We previously reported that spontaneous regeneration of the lateral olfactory tract (LOT), the main fiber tract of the central olfactory system, consistently occurred in newborn rats and a majority of these regenerated fibers were unmyelinated in neonatally LOT-transected young adult rats. To investigate the effects of ALC treatment on myelination in LOT, neonatal rats were treated with ALC after LOT transection. Immunohistochemistry for myelin basic protein showed more positive areas in ALC-treated rats than in control rats. Moreover, the number of myelinated axons of regenerated fibers was assessed using electron microscopy and was found to be statistically higher in ALC-treated rats compared to control rats. The study revealed that ALC accelerates myelination of regenerated fibers in neonatally LOT-injured young adult rats. (C) 2017 Elsevier B.V. All rights reserved.
Article
NEUROSCIENCE LETTERS.653:215-219(2017)
ELSEVIER IRELAND LTD
2017-06-03
eng
journal article
AM
http://hdl.handle.net/10091/00021598
https://soar-ir.repo.nii.ac.jp/records/20841
https://www.ncbi.nlm.nih.gov/pubmed/28583580
28583580
https://doi.org/10.1016/j.neulet.2017.06.001
10.1016/j.neulet.2017.06.001
0304-3940
AA00754925
NEUROSCIENCE LETTERS
653
215
219
https://soar-ir.repo.nii.ac.jp/record/20841/files/15K08131_01.pdf
application/pdf
1.1 MB
2019-09-09