2024-03-28T20:14:39Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00021732
2022-12-14T03:49:36Z
461:462
Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials
Sano, Mahoko
Izumiya, Makoto
Haniu, Hisao
Ueda, Katsuya
Konishi, Kosuke
Ishida, Haruka
Kuroda, Chika
Uemura, Takeshi
Aoki, Kaoru
Matsuda, Yoshikazu
Saito, Naoto
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
carbon nanohorn
carbon black
multi-walled carbon nanotube
lymphatic endothelial cells
cytotoxicity
cellular response
One of the greatest challenges to overcome in the pursuit of the medical application of carbon nanomaterials (CNMs) is safety. Particularly, when considering the use of CNMs in drug delivery systems (DDSs), evaluation of safety at the accumulation site is an essential step. In this study, we evaluated the toxicity of carbon nanohorns (CNHs), which are potential DDSs, using human lymph node endothelial cells that have been reported to accumulate CNMs, as a comparison to fibrous, multi-walled carbon nanotubes (MWCNTs) and particulate carbon black (CB). The effect of different surface characteristics was also evaluated using two types of CNHs (untreated and oxidized). In the fibrous MWCNT, cell growth suppression, as well as expression of inflammatory cytokine genes was observed, as in previous reports. In contrast, no significant toxicity was observed for particulate CB and CNHs, which was different from the report of CB cytotoxicity in vascular endothelial cells. These results show that (1) lymph endothelial cells need to be tested separately from other endothelial cells for safety evaluation of nanomaterials, and (2) the potential of CNHs as DDSs.
Article
NANOMATERIALS. 10(7):1374 (2020)
MDPI
2020-07
eng
journal article
VoR
http://hdl.handle.net/10091/00022489
https://soar-ir.repo.nii.ac.jp/records/21732
https://pubmed.ncbi.nlm.nih.gov/32674394
32674394
https://doi.org/10.3390/nano10071374
10.3390/nano10071374
2079-4991
NANOMATERIALS
10
7
1374
https://soar-ir.repo.nii.ac.jp/record/21732/files/nanomaterials-10-01374.pdf
application/pdf
9.9 MB
2021-02-04