2024-03-28T10:51:47Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00021947
2022-12-14T04:40:05Z
461:462
Electron Microscopy Observation of Human Pulmonary Ultrastructure in Two Patients with High-Altitude Pulmonary Edema
Droma, Yunden
Kato, Akane
Ichiyama, Takashi
Kobayashi, Nobumitsu
Honda, Takayuki
Uehara, Takeshi
Hanaoka, Masayuki
This is the accepted version of the following article: Electron Microscopy Observation of Human Pulmonary Ultrastructure in Two Patients with High-Altitude Pulmonary Edema. Yunden Droma, Akane Kato, Takashi Ichiyama, Nobumitsu Kobayashi, Takayuki Honda, Takeshi Uehara, and Masayuki Hanaoka. High Altitude Medicine & Biology 2017 18:3, 288-291, which has now been formally published in final form at High Altitude Medicine & Biology at https://doi.org/10.1089/ham.2016.0163. This original submission version of the article may be used for non-commercial purposes in accordance with the Mary Ann Liebert, Inc., publishers’ self-archiving terms and conditions.
electron microscopy
high-altitude pulmonary edema
pulmonary alveolar-capillary barrier
We examined the pulmonary ultrastructure in tissue from two patients with high-altitude pulmonary edema (HAPE) by electron microscopy. In one case, we found that neutrophils were trapped in pulmonary capillary lumen of alveolar-capillary wall and part of the cytoplasm of a neutrophil protruded and adhered to the capillary endothelium. There were several degranulated vacuoles in the cytoplasm of the neutrophil. The pulmonary capillary wall was deformed, thickened, and swollen and there was evidence of degeneration. In another case, infiltration of neutrophils and macrophages, proliferation of type II pneumocytes, and numerous red blood cells were also observed in alveolar air space. These electron microscopic ultrastructural observations illustrate for the first time damage to the pulmonary alveolar-capillary barrier in lung tissue of humans with advanced HAPE.
Article
HIGH ALTITUDE MEDICINE & BIOLOGY.18(3):288-291(2017)
MARY ANN LIEBERT, INC
2017-09-01
eng
journal article
AM
http://hdl.handle.net/10091/00022702
https://soar-ir.repo.nii.ac.jp/records/21947
https://www.ncbi.nlm.nih.gov/pubmed/28876136
28876136
https://doi.org/10.1089/ham.2016.0163
10.1089/ham.2016.0163
1527-0297
AA11647643
HIGH ALTITUDE MEDICINE & BIOLOGY
18
3
288
291
https://soar-ir.repo.nii.ac.jp/record/21947/files/16K09532_14.pdf
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2021-02-22