2024-03-29T11:45:54Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:02001260
2022-12-28T01:10:52Z
882:883
Metastases of soft tissue sarcoma to the liver: A Historical Cohort Study from a Hospital-based Cancer Registry
Okamoto, Masanori
Matsuoka, Masatake
Soma, Tamotsu
Arai, Ryuta
Kato, Hidenori
Harabayashi, Toru
Adachi, Hirohumi
Shinohara, Toshiki
Sagawa, Tamotsu
Nishiyama, Noriaki
Nambu, Toshikazu
Sakai, Wataru
Suzuki, Hiroaki
Kato, Hiroyuki
Hiraga, Hiroaki
© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
leiomyosarcoma
liver neoplasms
neoplasm metastasis
retroperitoneal neoplasm
soft tissue sarcoma
Background: Hepatic metastasis of soft tissue sarcoma is rare compared to lung metastasis, and the literature is scarce. We examined the risk of hepatic metastasis according to the site of occurrence and histological type. Methods: From a Hospital-based Cancer Registry, 658 patients registered between 2007 and 2017 with soft tissue sarcomas were evaluated. The exclusion criteria were gastrointestinal stromal tumors, tumors of unknown origin, and follow-up periods of less than 1 month. SPSS 25 was used for statistical analysis. Results: The risk of hepatic metastasis was significantly higher in the retroperitoneum (HR, 5.981; 95% CI, 2.793-12.808) and leiomyosarcoma (HR, 4.303; 95% CI, 1.782-10.390). Multivariate analysis showed that the risk of hepatic metastasis as first distant metastasis was high in leiomyosarcoma (HR, 4.546; 95% CI, 2.275-9.086) and retroperitoneal onset (HR, 4.588; 95% CI, 2.280-9.231). The 2-year survival rate after hepatic metastasis was 21.7%. Conclusions: The onset of hepatic metastasis indicates a poor prognosis. However, hepatic metastasis from retroperitoneal sarcoma and leiomyosarcoma may be the first distant metastasis in some cases. For retroperitoneal sarcoma and leiomyosarcoma, additional screening for hepatic metastasis such as contrast CT should be considered during staging and follow-up after treatment.
Article
Cancer medicine 17(17) : 6159-6165(2020)
Wiley
2020-09
eng
journal article
VoR
http://hdl.handle.net/10091/0002001260
https://soar-ir.repo.nii.ac.jp/records/2001260
https://pubmed.ncbi.nlm.nih.gov/32648686/
32648686
https://doi.org/10.1002/cam4.3304
10.1002/cam4.3304
2045-7634
Cancer medicine
17
17
6159
6165
https://soar-ir.repo.nii.ac.jp/record/2001260/files/18K16651_1.pdf
application/pdf
2022-12-28