2024-03-29T11:57:40Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:02001266
2022-12-28T01:57:27Z
882:883
Initial clinical presentation of single soft tissue metastasis of medullary thyroid carcinoma without primary tumor in the thyroid gland
Okamoto, Masanori
Takazawa, Akira
Aoki, Kaoru
Yoshimura, Yasuo
Kato, Hiroyuki
Otsuki, Toshiaki
Maeno, Kazuma
Koizumi, Tomonobu
© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Primary unknown origin
Calcitonin
TTF-1
Soft tissue metastasis
CEA
Background: Single soft tissue metastasis of medullary thyroid carcinoma is extremely rare. In addition, several occult medullary thyroid carcinomas with distant metastasis were reported, but undetectable primary lesion at diagnosis was also extremely rare. Case presentation: A 74-year-old man was admitted to our hospital because of a painful nodule in his left buttock for over 1 year. Needle biopsy was performed, and the histological findings revealed adenocarcinoma positive for thyroid transcription factor-1. No evidence of a primary tumor, including the lung and thyroid gland, could be found elsewhere despite detailed examinations, including thyroid echography, chest computed tomography, and fluorodeoxyglucose-positron emission tomography. The soft tissue tumor was resected with a wide margin. Immunohistochemical analysis showed the tumor cells to be positive for cytokeratin-AE1/3, cytokeratin 7, synaptophysin, chromogranin A, calcitonin, and carcinoembryonic antigen, but negative for cytokeratin 20, Napsin A, Pax8, and p40, resulting in a diagnosis of metastasis of medullary thyroid carcinoma. Conclusion: Initial presentation with a single metastasis to soft tissue and undetectable primary tumor in the thyroid gland is an extremely rare clinical manifestation in patients with medullary thyroid carcinoma.
Article
World journal of surgical oncology 15(1) : 221(2017)
BioMed Central
2017-12-13
eng
journal article
VoR
http://hdl.handle.net/10091/0002001266
https://soar-ir.repo.nii.ac.jp/records/2001266
https://pubmed.ncbi.nlm.nih.gov/29237502/
29237502
https://doi.org/10.1186/s12957-017-1293-2
10.1186/s12957-017-1293-2
1477-7819
World journal of surgical oncology
15
1
221
https://soar-ir.repo.nii.ac.jp/record/2001266/files/WJSO15_221.pdf
application/pdf
2022-12-28