2024-03-29T08:54:32Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:02001272
2023-01-19T05:29:43Z
1309:1310
Maternal GABAergic and GnRH/corazonin pathway modulates egg diapause phenotype of the silkworm Bombyx mori
Tsuchiya, Ryoma
Kaneshima, Aino
Kobayashi, Masakazu
Yamazaki, Maki
Takasu, Yoko
Sezutsu, Hideki
Tanaka, Yoshiaki
Mizoguchi, Akira
Shiomi, Kunihiro
diapause hormone
corazonin
GABA
GABA transporter
Bombyx mori
Diapause represents a major developmental switch in insects and is a seasonal adaptation that evolved as a specific subtype of dormancy in most insect species to ensure survival under unfavorable environmental conditions and synchronize populations. However, the hierarchical relationship of the molecular mechanisms involved in the perception of environmental signals to integration in morphological, physiological, behavioral, and reproductive responses remains unclear. In the bivoltine strain of the silkworm Bombyx mori, embryonic diapause is induced transgenerationally as a maternal effect. Progeny diapause is determined by the environmental temperature during embryonic development of the mother. Here, we show that the hierarchical pathway consists of a gamma-aminobutyric acid (GABA)ergic and corazonin signaling system modulating progeny diapause induction via diapause hormone release, which may be finely tuned by the temperature-dependent expression of plasma membrane GABA transporter. Furthermore, this signaling pathway possesses similar features to the gonadotropin-releasing hormone (GnRH) signaling system for seasonal reproductive plasticity in vertebrates.
Article
Proceedings of The National Academy of Sciences of The United States of America 118(1) : e2020028118-(2021)
National Academy of Sciences
2021-01-05
eng
journal article
VoR
http://hdl.handle.net/10091/0002001272
https://soar-ir.repo.nii.ac.jp/records/2001272
https://doi.org/10.1073/pnas.2020028118
10.1073/pnas.2020028118
1091-6490
Proceedings of The National Academy of Sciences of The United States of America
118
1
e2020028118
https://soar-ir.repo.nii.ac.jp/record/2001272/files/17H03941_2.pdf
application/pdf
2023-01-19
https://soar-ir.repo.nii.ac.jp/record/2001272/files/17H03941_2spl.pdf
application/pdf
4.5 MB
2023-01-19