2024-03-29T01:58:57Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003673
2022-12-14T03:49:15Z
461:462
Cold stress induces lower urinary tract symptoms
Imamura, Tetsuya
Ishizuka, Osamu
Nishizawa, Osamu
C-fiber
cold stress
detrusor overactivity
lower urinary tract symptoms
transient receptor potential melastatin 8 channel
Cold stress as a result of whole-body cooling at low environmental temperatures exacerbates lower urinary tract symptoms, such as urinary urgency, nocturia and residual urine. We established a model system using healthy conscious rats to explore the mechanisms of cold stress-induced detrusor overactivity. In this review, we summarize the basic findings shown by this model. Rats that were quickly transferred from room temperature (27 +/- 2 degrees C) to low temperature (4 +/- 2 degrees C) showed detrusor overactivity including increased basal pressure and decreased voiding interval, micturition volume, and bladder capacity. The cold stress-induced detrusor overactivity is mediated through a resiniferatoxin-sensitve C-fiber sensory nerve pathway involving 1-adrenergic receptors. Transient receptor potential melastatin8 channels, which are sensitive to thermal changes below 25-28 degrees C, also play an important role in mediating the cold stress responses. Additionally, the sympathetic nervous system is associated with transient hypertension and decreases of skin surface temperature that are closely correlated with the detrusor overactivity. With this cold stress model, we showed that 1-adrenergic receptor antagonists have the potential to treat cold stress-exacerbated lower urinary tract symptoms. In addition, we showed that traditional Japanese herbal mixtures composed of Hachimijiogan act, in part, by increasing skin temperature and reducing the number of cold sensitive transient receptor potential melastatin channels in the skin. The effects of herbal mixtures have the potential to treat and/or prevent the exacerbation of lower urinary tract symptoms by providing resistance to the cold stress responses. Our model provides new opportunities for utilizing animal disease models with altered lower urinary tract functions to explore the effects of novel therapeutic drugs.
Article
INTERNATIONAL JOURNAL OF UROLOGY. 20(7):661-669 (2013)
journal article
WILEY-BLACKWELL
2013-07
application/pdf
INTERNATIONAL JOURNAL OF UROLOGY
7
20
661
669
0919-8172
AA11042471
https://soar-ir.repo.nii.ac.jp/record/3673/files/Cold_stress_induces_lower_urinary.pdf
eng
23441811
https://pubmed.ncbi.nlm.nih.gov/23441811
10.1111/iju.12129
https://doi.org/10.1111/iju.12129
Copyright© 2013 The Japanese Urological Association