2024-03-19T08:37:34Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003724
2022-12-14T03:49:08Z
461:462
Expression of Various Glutamate Receptors Including N-Methyl-D-Aspartate Receptor (NMDAR) in an Ovarian Teratoma Removed from a Young Woman with Anti-NMDAR Encephalitis
Tachibana, Naoko
Shirakawa, Takashi
Ishii, Keiko
Takahashi, Yukitoshi
Tanaka, Keiko
Arima, Kunimasa
Yoshida, Takuhiro
Ikeda, Shu-ichi
limbic encephalitis
paraneoplastic syndrome
ovarian teratoma
glutamate receptor
N-methyl-D-aspartate receptor (NMDAR)
A 21-year-old woman developed psychiatric symptoms, progressive unresponsiveness, generalized seizures, severe dyskinesia, marked fluctuation of blood pressure, and hypersalivation after a flu-like episode. Anti-glutamate receptor (GluR)epsilon 2 and anti-N-methyl-D-aspartate receptor (NMDAR) antibodies were positive in both her serum and CSF. After she recovered five months later she underwent surgery to remove a right ovarian teratoma. Immunohistochemical examinations of her teratoma disclosed abundant expression of various GluRs including NR2B subunit of NMDAR, GluR1, and GluR2/3. These immunoreactivities of GluRs were seen not only in small areas of neural tissue identified as anti-glial fibrillary acidic protein (GFAP)-immunoreactive areas but also in other large areas of undifferentiated neuroepithelial tissue without GFAP immunoreactivity. Our findings strongly support the recent idea that neural elements in ovarian teratoma play an important role in the production of antibodies to NMDARs in anti-NMDAR encephalitis. Additionally, the study of control ovaries clearly showed NR2B-related immunoreactivity in the cytoplasm of oocytes, indicating that the normal ovary itself has expression of NMDARs. This finding might provide a clue to understand the pathogenesis of this disease in female patients without ovarian teratoma.
Article
INTERNAL MEDICINE. 49(19):2167-2173 (2010)
journal article
JAPAN SOC INTERNAL MEDICINE
2010
application/pdf
INTERNAL MEDICINE
19
49
2167
2173
0918-2918
AA10827774
https://soar-ir.repo.nii.ac.jp/record/3724/files/Expression_Various_Glutamate_Receptors_Including_N-Methyl-D-Aspartate.pdf
eng
20930449
https://pubmed.ncbi.nlm.nih.gov/20930449
10.2169/internalmedicine.49.4069
https://doi.org/10.2169/internalmedicine.49.4069
Copyright© 2010 The Japanese Society of Internal Medicine