2024-03-29T12:01:30Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003738
2022-12-14T04:39:37Z
461:462
Prospective Study of Gefitinib Readministration After Chemotherapy in Patients With Advanced Non-Small-Cell Lung Cancer Who Previously Responded to Gefitinib
Koizumi, Tomonobu
Agatsuma, Toshihiko
Ikegami, Kayoko
Suzuki, Toshiro
Kobayashi, Takashi
Kanda, Shintaro
Yoshikawa, Sumiko
Kubo, Keishi
Shiina, Takayuki
Takasuna, Keiichirou
Matsuo, Akemi
Hayasaka, Muneharu
Morikawa, Miwa
Ameshima, Shingo
Chemotherapy
EGFR mutation
Epidermal growth factor receptor tyrosine kinase inhibitor
Gefitinib responder
Non-small-cell lung cancer
Recharrenge
The present study was designed to prospectively evaluate the clinical efficacy of gefitinib readministration in patients with advanced non-small cell lung cancer who responded well to initial gefitinib, followed by cytotoxic chemotherapy. Twenty subjects were enrolled, and 3 and 6 patients achieved partial response and stable disease, respectively. These findings provide valuable information for the management of previous gefitinib responders. Introduction: Salvage treatment for acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitor in patients with non-small-cell lung cancer is a matter of clinical concern. Several retrospective reports have indicated the usefulness of epidermal growth factor receptor tyrosine kinase inhibitor readministration; however, there have been few prospective studies. Materials and Methods: This study was designed to prospectively evaluate the clinical efficacy of gefitinib readministration in patients with advanced or metastatic non-small-cell lung cancer who responded well to initial gefitinib treatment. The subjects received at least 1 regimen of cytotoxic chemotherapy after progressive disease with the initial gefitinib therapy. Gefitinib administration (250 mg/d, orally) was started after progressive disease with the previous chemotherapeutic regimen. The primary endpoint in the present study was the response rate. Results: Twenty patients were enrolled between April 2007 and May 2011. Three patients achieved partial response, and 6 showed stable disease. Thus, the overall response rate and disease control rate of gefitinib readministration were 15% (95% Cl, 3.21-37.9) and 45% (95% Cl, 23.1-68.5), respectively. Median progression-free survival and overall survival from the start of gefitinib readministration were 2.0 months (95% Cl, 0.9-3.1 months) and 12.0 months (95% Cl, 8.0-16.0 months), respectively. Conclusion: These results suggest that gefitinib readministration may be an option, albeit with a low response rate and short progression-free survival, for patients who responded well to initial gefitinib followed by systemic chemotherapy. These findings provide valuable information for the management of previous gefitinib responders.
Article
CLINICAL LUNG CANCER. 13(6):458-463 (2012)
journal article
CIG MEDIA GROUP, LP
2012-11
application/pdf
CLINICAL LUNG CANCER
6
13
458
463
1525-7304
AA11973261
https://soar-ir.repo.nii.ac.jp/record/3738/files/Prospective_study_gefitinib_readministration_after_chemotherapy.pdf
eng
22402083
https://pubmed.ncbi.nlm.nih.gov/22402083
10.1016/j.cllc.2012.01.006
https://doi.org/10.1016/j.cllc.2012.01.006
Copyright© 2012 Elsevier