2024-03-29T07:04:43Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003743
2022-12-14T04:39:37Z
461:462
Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: Morphological significance of calponin h1
Hayashi, Takuma
Horiuchi, Akiko
Sano, Kenji
Hiraoka, Nobuyoshi
Kasai, Mari
Ichimura, Tomoyuki
Sudo, Tamotsu
Nishimura, Ryuichiro
Ishiko, Osamu
Shiozawa, Tanri
Kanai, Yae
Yaegashi, Nobuo
Aburatani, Hiroyuki
Konishi, Ikuo
LMP2
Calponin h1
Uterine leiomyosarcoma
Cell morphology
Uterine leiomyosarcoma (LMS) is a highly metastatic smooth muscle neoplasm for which calponin h1 is suspected to have a biological role as a tumor-suppressor. We earlier reported that LMP2-null mice spontaneously develop uterine LMS through malignant transformation of the myometrium, thus implicating this protein as an anti-tumorigenic candidate as well. In the present study, we show that LMP2 may negatively regulate LMS independently of its role in the proteasome. Moreover, several lines of evidence indicate that although calponin h1 does not directly influence tumorigenesis, it clearly affects LMP2-induced cellular morphological changes. Modulation of LMP2 may lead to new therapeutic approaches in human uterine LMS.
Article
FEBS LETTERS. 586(13):1824-1831 (2012)
journal article
ELSEVIER SCIENCE BV
2012-06-21
application/pdf
FEBS LETTERS
13
586
1824
1831
0014-5793
AA00642943
https://soar-ir.repo.nii.ac.jp/record/3743/files/Potential_role_LMP2_anti-oncogenic_factor.pdf
eng
22659265
https://pubmed.ncbi.nlm.nih.gov/22659265
10.1016/j.febslet.2012.05.029
https://doi.org/10.1016/j.febslet.2012.05.029
Copyright© 2012 Federation of European Biochemical Societies. Published by Elsevier B. V.