2024-03-29T08:32:08Z
https://soar-ir.repo.nii.ac.jp/oai
oai:soar-ir.repo.nii.ac.jp:00003755
2022-12-14T04:39:39Z
461:462
Myocardial Performance Index in Subjects Susceptible to High-Altitude Pulmonary Edema
Hanaoka, Masayuki
Kogashi, Kaoru
Droma, Yunden
Urushihata, Kazuhisa
Kubo, Keishi
Doppler examination
hypoxia
myocardial performance
pulmonary hypertension
Tei index
Objective A recent study concerning high-altitude pulmonary edema (HAPE), a non-cardiogenic pulmonary edema, suggested that it is initially a hydrostatic-type pulmonary edema. We suspect that some extent of cardiac insufficiency may likely relate to the mechanism of the development of this disease. Methods By Doppler echocardiography, the Tei index (a new quantitative index proposed for the evaluation of global myocardial performance) and the systolic pulmonary artery pressure (sPAP) were measured before and after 30 minutes of hypoxic breathing. Patients Eleven HAPE-susceptible subjects (HAPE-s) and nine HAPE-resistant subjects (HAPE-r). Results The results of Tei index indicated an enhanced left myocardial performance but an impaired right performance in HAPE-s during hypoxic breathing. The sPAP of HAPE-s was significantly increased after hypoxic breathing, which was not correlated with the heart functions such as right ventricular (RV) Tei index, cardiac index (CI), percent ejection fraction (EF%) and percent fractional shortening (FS%) under hypoxic condition. Comparatively, the HAPE-r subjects did not show such significant changes of Tei index after hypoxic breathing. The results suggested that a paradoxical myocardial performance, in a format of an augmented left ventricular (LV) in contrast to an attenuated RV, was observed in the HAPE-s exposed to acute hypoxia. Conclusion The responses of the left and right myocardial performances to hypoxia may be involved in the pathogenesis of HAPE.
Article
INTERNAL MEDICINE. 50(24):2967-2973 (2011)
journal article
JAPAN SOC INTERNAL MEDICINE
2011
application/pdf
INTERNAL MEDICINE
24
50
2967
2973
0918-2918
AA10827774
https://soar-ir.repo.nii.ac.jp/record/3755/files/Myocardial_Performance_Index_Subjects_Susceptible.pdf
eng
22185987
https://pubmed.ncbi.nlm.nih.gov/22185987
10.2169/internalmedicine.50.5942
https://doi.org/10.2169/internalmedicine.50.5942
Copyright© 2011 The Japanese Society of Internal Medicine